以下是引用 nineteen 的发言： 大娃周三晚上开始发烧，最高到103度多周四上午我发现他喉咙里有泡，看医生检查出strep throat，开了抗生素今天周五他不怎么烧了，但是下午发现他手脚都起泡了，他说泡很痛晚........ ★ Sent from iPhone App: i-Reader Huaren Lite 7.52
我查了两个参考书： 1. Micromedex： Ear, nose, and throat infection: greater than 3 months of age, less than 40 kg, mild to moderate infections, 25 mg/kg/day ORALLY divided every 12 hr or 20 mg/kg/day divided every 8 hr [2]
the correct dosage for amoxicillin for strep throat is 50mg/kg 1 time daily for 10 days. So your pediatrician is correct. The twice daily dosage is not for strep throat, but for other conditions.
我查了两个参考书： 1. Micromedex： Ear, nose, and throat infection: greater than 3 months of age, less than 40 kg, mild to moderate infections, 25 mg/kg/day ORALLY divided every 12 hr or 20 mg/kg/day divided every 8 hr [2]
the correct dosage for amoxicillin for strep throat is 50mg/kg 1 time daily for 10 days. So your pediatrician is correct. The twice daily dosage is not for strep throat, but for other conditions.
Amoxicillin 这类penicillin antibiotics is Time-dependent killing, which means you have to have enough time in which the drug concentration is above MIC to have the best effect. So in my opinion, BID dosing is quite important in general regardless of indication. Amoxicillin has pretty mild side effect profile, it won't hurt to give a little more as long as your kid is well hydrated.
yes, I support our answer. Amoxcillin is time above MIC drug. that's why we should split the dose. no matter what, dosing has to make sense pharmacokinetically. Drugs like Amoxicillin I don't think it will hurt much to give a little more. As long as the patient's kidney function is good. I will recommend 400mg twice daily or 600mg twice daily.
我查了两个参考书： 1. Micromedex： Ear, nose, and throat infection: greater than 3 months of age, less than 40 kg, mild to moderate infections, 25 mg/kg/day ORALLY divided every 12 hr or 20 mg/kg/day divided every 8 hr [2]
请问您用的哪个guideline? 我只能查到750mg PO QD是对于4岁到14岁小孩FDA没有通过的疗法。
[此贴子已经被作者于2012/3/31 23:05:15编辑过]
I am a physician. No offense, but the clinical medicine we practice are not the same as whats in your books. New studies are coming out all the time and multiple studies support the use of once daily dozing. This is called Evidenced based medicine.
This is why we go through residency. If we can learn everything from the text book, then we can all be physicians. [此贴子已经被作者于2012/4/15 15:11:41编辑过]
I am a physician. The clinical medicine we practice are not the same as your books.
Clinical medicines should be Evidence based medicine. I can only find in guidelines 775 mg daily dosage are adult dosage or for children 12 yrs or older (which is the "b" indicates). The guidelines we used are American Pediatric Society endorsed guidelines. I don't know what guidelines physicians use, or they create their own guidelines.
Clinical medicines should be Evidence based medicine. The guidelines we used are American Pediatric Society endorsed guidelines. I don't know what guidelines physicians use, or they create their own guidelines.
You need to do some more research then. Guidelines are changing all the time.
Multiple studies have shown that one time daily dosing of Amoxcillin is just as effective. It also greatly improves patient compliance. The guidelines may not be changing as quickly. Medicine is a field that's evolving very quickly. By the time you graduate, the guideline might be a lot different.
Multiple studies have shown that one time daily dosing of Amoxcillin is just as effective. It also greatly improves patient compliance. The guidelines may not be changing as quickly. Medicine is a field that's evolving very quickly. By the time you graduate, the guideline might be a lot different.
Studies can be biased. That is why there are millions of studies but not as many reputable guidelines. I agree the guideline might be different be there are always updates. Also one need to take clinical judgments into account as well. That is way different physicians have different opinions.
Anyway,I am really not here to argue with you. Life is too short. have a good one~~
Source Eastover Pediatrics, Charlotte, NC 28204, USA. [email protected]
Abstract BACKGROUND: Two relatively small previous studies comparing once-daily amoxicillin with conventional therapy for group A streptococcal (GAS) pharyngitis reported similar rates of bacteriologic success for each treatment group. The purpose of this study was to further evaluate once-daily amoxicillin for GAS pharyngitis in a larger study. METHODS: In a single pediatric practice, from October through May for 2 consecutive years (2001-2003), we recruited children 3 to 18 years of age who had symptoms and signs suggestive of GAS pharyngitis. Patients with a positive rapid test for GAS were stratified by weight (<40 kg or >or=40 kg) and then randomly assigned to receive once-daily (750 mg or 1000 mg) or twice-daily (2 doses of 375 mg or 500 mg) amoxicillin for 10 days. We determined bacteriologic failure rates for GAS in the pharynx from subsequent swabs taken at 14 to 21 (visit 2) and 28 to 35 (visit 3) days after treatment initiation. We conducted a randomized, controlled, investigator-blinded, noninferiority trial to evaluate whether amoxicillin given once daily would have a bacteriologic failure rate no worse than that of amoxicillin given twice daily within a prespecified margin of 10%. GAS isolates were characterized to distinguish bacteriologic failures from new acquisitions. Adverse events were described and adherence was evaluated by review of returned daily logs and dosage bottles. RESULTS: Of 2139 potential study patients during the 2-year period, we enrolled 652 patients, 326 into each treatment group. Children in the 2 groups were comparable with respect to all demographic and clinical characteristics except that children <40 kg more often presented with rash in each treatment group. At visit 2, failure rates were 20.1% (59 of 294) for the once-daily group and 15.5% (46 of 296) for the twice-daily group (difference, 4.53%; 90% confidence interval [CI], -0.6 to 9.7). At visit 3, failure rates were 2.8% (6 of 216) for the once-daily group and 7.1% (16 of 225) for the twice-daily group (difference, -4.33; 90% CI, -7.7 to -1.0). Gastrointestinal and other adverse events occurred in the once-daily treatment group with a frequency comparable to that in the twice-daily treatment group. Presumed allergic reactions occurred in 0.9% (6 of 635). More than 95% (516 of 541) of patients complied with 10 days of therapy with no significant differences between groups. CONCLUSIONS: We conclude that amoxicillin given once daily is not inferior to amoxicillin given twice daily. Gastrointestinal and other events did not occur significantly more often in the once-daily treatment group. From the data in this large, investigator-blinded, controlled study, once-daily amoxicillin appears to be a suitable regimen for treatment of GAS pharyngitis.
At least from this study, once daily dosing is noninferior to twice daily dosing. So, I guess you can argue either way, because a lot of what we do in practice are hard to draw a line. For those compliance is not a issue, there is nothing wrong with twice daily dosing either.
I believe by now LZ's child should have already recovered. :)
4.3 二娃泡泡还在增多，密密麻麻的小红点，看着很吓人。
有的长大了，变成中间一个水泡，有的就是个小点。
中午吃了点蛋饼和酸奶，其他时候主要靠goldfish撑着。
本来很爱喝水的娃，还是不肯主动喝水，只能靠针管。
夜里睡的也不踏实。总是半夜哭闹一次。
中午有点点热，99度多这样。下午又不热了。
今天一天都没有吃退烧药。
4。2是二娃悲惨的一天。
泡泡全面爆发，不尽手足口上，下巴肩膀耳朵屁股上都有，腿上更是一片片的。
二娃很烦躁，不愿吃不愿喝，我不得不用针管给他喂水。
中饭晚饭都是站在水池边上玩着水才哄进去一盒酸奶半盒糊糊，晚上临睡前大概饿坏了，吃了很多goldfish。
下午还有点烧，100这样。医生说如果5天不退再去看。
4.1 今天大娃完全不烧了，他说喉咙也不怎么疼了，吃饭也基本恢复正常
手上和脚上的泡略有增加，不过不痛也不痒
二娃今天还有烧100到101这样，左脚底板有几个小泡要发出来的样子
不愿吃东西，勉强吃了点小面包和chicken ramen，还有酸奶
喝水还凑活，不烧不fussy的时候会主动喝水
。。。。。。。。。。。。。。。。。
3.31 今天上午问了pharmacist，说是一天2tsp的量是对的，但是建议分两次吃。
然后又问了我们的ped，她说就strep throat可以一天一次，中耳炎之类的就要一天两次，如果我们想要一天两次也可以。
大娃今天基本不烧了，不过手上脚下和嘴唇的泡还在增加，他时不时抱怨很痛，不过精神总的来说还可以
二娃今天就惨了，开始高烧，人很蔫，不愿吃也不愿喝
谢谢大家的祝福！希望俩娃快快好，二娃抗住，千万别脱水。
------------------------------
3。30 大娃周三晚上开始发烧，最高到103度多
周四上午我发现他喉咙里有泡，看医生检查出strep throat，开了抗生素
今天周五他不怎么烧了，但是下午发现他手脚都起泡了，他说泡很痛
晚上带他看after hour的ped，医生说他同时得了手足口。。。
晚上还带了二娃去检查，也证实得了strep throat，估计过两天手足口也难逃
我们还有10天乘飞机回国，希望Bless俩娃都能在10天内好彻底啊！
。。。。。。。。。。。
。。。。。。。。。。。
还有个更郁闷的事希望学药剂学的姐妹帮我看看
我们自己的ped给开了amoxicillin
400mg per 5ml的
大娃36lb
我们的ped说一次吃2 teaspoons，一天一次就行了
可是after hour clinic的ped说一次2 tsps，一天要吃2次！
谁对谁错啊???????
[此贴子已经被作者于2012/4/5 0:39:00编辑过]
BLESS! 要不给儿医打电话确认一下.
打了，儿医坚持她是对的
★ Sent from iPhone App: i-Reader Huaren Lite 7.39
★ Sent from iPhone App: i-Reader Huaren Lite 7.52
以下是引用 nineteen 的发言：
大娃周三晚上开始发烧，最高到103度多周四上午我发现他喉咙里有泡，看医生检查出strep throat，开了抗生素今天周五他不怎么烧了，但是下午发现他手脚都起泡了，他说泡很痛晚........
★ Sent from iPhone App: i-Reader Huaren Lite 7.52
大娃周三晚上开始发烧，最高到103度多
周四上午我发现他喉咙里有泡，看医生检查出strep throat，开了抗生素
今天周五他不怎么烧了，但是下午发现他手脚都起泡了，他说泡很痛
晚上带他看after hour的ped，医生说他同时得了手足口。。。
晚上还带了二娃去检查，也证实得了strep throat，估计过两天手足口也难逃
我们还有10天乘飞机回国，希望Bless俩娃都能在10天内好彻底啊！
。。。。。。。。。。。
。。。。。。。。。。。
还有个更郁闷的事希望学药剂学的姐妹帮我看看
我们自己的ped给开了amoxicillin
400mg per 5ml的
大娃36lb
我们的ped说一次吃2 teaspoons，一天一次就行了
可是after hour clinic的ped说一次2 tsps，一天要吃2次！
谁对谁错啊???????
[此贴子已经被作者于2012/3/31 0:50:38编辑过]
bless!
follow ped. But for antibiotics, it is ok and sometimes suggested to double the dose for the first time. But I do not know for kids.
child: oral range 25-50mg/kg/day. (max: 60-80mg/kg/day) divided every 8 hour or 200-400mg every 12 hour.
根据你儿子的体重. 16.3kg -----> 407mg-815mg per day. 我的推断是 一天一次, 每次２tsp 这就已经吃了８００ｍｇ了.
after hour 的医生, 估计是一天两次,每次一ｔｓｐ吧.
如果单独服用的话，口服的Amoxicillin 有60％ 在6到8个小时就已经从体内排出了。所以最好每12小时吃一次。但是这个医生开的剂量很大，不应该一天吃两次。解释如下：
我查了两个参考书：
1. Micromedex：
Ear, nose, and throat infection: greater than 3 months of age, less than
40 kg, mild to moderate infections, 25 mg/kg/day ORALLY divided every
12 hr or 20 mg/kg/day divided every 8 hr [2]
2. Clinical Pharmacology
For the treatment of upper respiratory tract infections (e.g., sinusitis, pharyngitis, tonsillitis):
?for mild to moderate infections caused by highly susceptible organisms:
Oral dosage:
Adults, Adolescents, and Children (weight >= 40 kg): 500 mg PO every 12 hours or 250 mg PO every 8 hours.
Children (weight < 40 kg):
45—90 mg/kg/day PO given in divided doses every 12 hours is recommended
by the American Academy of Pediatrics (AAP) for bacterial sinusitis.[40714]
Although the AAP does not specify a total mg/day maximum dose, adult
doses should not be exceeded as a general rule. The AAP does not
recommend amoxicillin for patients with severe sinusitis or risk factors
for resistant organisms such as day care attendance or recent exposure
(< 90 days) to antibiotics. The AAP suggests that age less than 2
years may also be a risk factor for amoxicillin-resistant organisms.[40714]
The manufacturer recommends 20 mg/kg/day PO given in equally divided
doses every 8 hours or 25 mg/kg/day PO in equally divided doses given
every 12 hours for mild to moderate infections.[28047]
我认为应该一天吃两次，每隔12小时吃一次，儿医的药量给得很高。大人的量是500mg 每12小时。按照美国儿医协会的推荐，小孩的量不要超过大人的剂量。这个医生开的是800mg每次。这个剂量不应该一天两次。
第一个儿医的方法也可能有疗效，但是不是最好的疗效。
我现在是Pharmacy student, 刚刚学过抗生素，所有的只是建议。mm可以到mitbbs pharmacy 版问问。
或者到pharmacy 咨询的地方，专门问问pharmacist， key word is dosage 和frequency.
Bless mm～～
[此贴子已经被作者于2012/3/31 10:58:17编辑过]
bless
[此贴子已经被作者于2012/3/31 11:58:08编辑过]
大娃周三晚上开始发烧，最高到103度多 周四上午我发现他喉咙里有泡，看医生检查出strep throat，开了抗生素 今天周五他不怎么烧了，但是下午发现他手脚都起泡了，他说泡很痛 晚上带他看after hour的ped，医生说他同时得了手足口。。。 晚上还带了二娃去检查，也证实得了strep throat，...... bless!!
★ 发自Android 华人阅览器 4.0.7
Amoxicillin 是penicillin的一种，在体内需要到一个最小的浓度才有有杀菌作用。对于penicillin类药物，需要体内浓度大于这个最小浓度的时间大于一个数值才有最好的临床疗效。
如果单独服用的话，口服的Amoxicillin 有60％ 在6到8个小时就已经从体内排出了。所以最好每12小时吃一次。但是这个医生开的剂量很大，不应该一天吃两次。解释如下：
我查了两个参考书：
1. Micromedex：
Ear, nose, and throat infection: greater than 3 months of age, less than 40 kg, mild to moderate infections, 25 mg/kg/day ORALLY divided every 12 hr or 20 mg/kg/day divided every 8 hr [2]
2. Clinical Pharmacology
For the treatment of upper respiratory tract infections (e.g., sinusitis, pharyngitis, tonsillitis):
?for mild to moderate infections caused by highly susceptible organisms:
Oral dosage:
Adults, Adolescents, and Children (weight >= 40 kg): 500 mg PO every 12 hours or 250 mg PO every 8 hours.
Children (weight < 40 kg): 45—90 mg/kg/day PO given in divided doses every 12 hours is recommended by the American Academy of Pediatrics (AAP) for bacterial sinusitis.[40714] Although the AAP does not specify a total mg/day maximum dose, adult doses should not be exceeded as a general rule. The AAP does not recommend amoxicillin for patients with severe sinusitis or risk factors for resistant organisms such as day care attendance or recent exposure (< 90 days) to antibiotics. The AAP suggests that age less than 2 years may also be a risk factor for amoxicillin-resistant organisms.[40714] The manufacturer recommends 20 mg/kg/day PO given in equally divided doses every 8 hours or 25 mg/kg/day PO in equally divided doses given every 12 hours for mild to moderate infections.[28047]
我认为应该一天吃两次，每隔12小时吃一次，儿医的药量给得很高。大人的量是500mg 每12小时。按照美国儿医协会的推荐，小孩的量不要超过大人的剂量。这个医生开的是800mg每次。这个剂量不应该一天两次。
第一个儿医的方法也可能有疗效，但是不是最好的疗效。
我现在是Pharmacy student, 刚刚学过抗生素，所有的只是建议。mm可以到mitbbs pharmacy 版问问。
或者到pharmacy 咨询的地方，专门问问pharmacist， key word is dosage 和frequency.
Bless mm～～
[此贴子已经被作者于2012/3/31 10:58:17编辑过]
dosage for strep throat is 50mg/kg PO Qday.
pharmacist 比儿医生懂得多些（对于药来说），去药房问吧。
bless
dosage for strep throat is 50mg/kg PO Qday.
请问您用的哪个guideline?
我只能查到750mg PO QD是对于4岁到14岁小孩FDA没有通过的疗法。
[此贴子已经被作者于2012/3/31 23:05:15编辑过]
the correct dosage for amoxicillin for strep throat is 50mg/kg 1 time daily for 10 days. So your pediatrician is correct. The twice daily dosage is not for strep throat, but for other conditions.
今天ped也是这么说，说是去年11月她们参加的一个什么conference里说的
Drugs like Amoxicillin I don't think it will hurt much to give a little more. As long as the patient's kidney function is good.
I will recommend 400mg twice daily or 600mg twice daily.
以下是引用crisom在3/31/2012 10:27:00 AM的发言：
Amoxicillin 是penicillin的一种，在体内需要到一个最小的浓度才有有杀菌作用。对于penicillin类药物，需要体内浓度大于这个最小浓度的时间大于一个数值才有最好的临床疗效。
如果单独服用的话，口服的Amoxicillin 有60％ 在6到8个小时就已经从体内排出了。所以最好每12小时吃一次。但是这个医生开的剂量很大，不应该一天吃两次。解释如下：
我查了两个参考书：
1. Micromedex：
Ear, nose, and throat infection: greater than 3 months of age, less than
40 kg, mild to moderate infections, 25 mg/kg/day ORALLY divided every
12 hr or 20 mg/kg/day divided every 8 hr [2]
2. Clinical Pharmacology
For the treatment of upper respiratory tract infections (e.g., sinusitis, pharyngitis, tonsillitis):
?for mild to moderate infections caused by highly susceptible organisms:
Oral dosage:
Adults, Adolescents, and Children (weight >= 40 kg):
500 mg PO every 12 hours or 250 mg PO every 8 hours.
Children (weight < 40 kg):
45—90 mg/kg/day PO given in divided doses every 12 hours is recommended
by the American Academy of Pediatrics (AAP) for bacterial sinusitis.[40714]
Although the AAP does not specify a total mg/day maximum dose, adult
doses should not be exceeded as a general rule. The AAP does not
recommend amoxicillin for patients with severe sinusitis or risk factors
for resistant organisms such as day care attendance or recent exposure
(< 90 days) to antibiotics. The AAP suggests that age less than 2
years may also be a risk factor for amoxicillin-resistant organisms.[40714]
The manufacturer recommends 20 mg/kg/day PO given in equally divided
doses every 8 hours or 25 mg/kg/day PO in equally divided doses given
every 12 hours for mild to moderate infections.[28047]
我认为应该一天吃两次，每隔12小时吃一次，儿医的药量给得很高。大人的量是500mg 每12小时。按照美国儿医协会的推荐，小孩的量不要超过大人的剂量。这个医生开的是800mg每次。这个剂量不应该一天两次。
第一个儿医的方法也可能有疗效，但是不是最好的疗效。
我现在是Pharmacy student, 刚刚学过抗生素，所有的只是建议。mm可以到mitbbs pharmacy 版问问。
或者到pharmacy 咨询的地方，专门问问pharmacist， key word is dosage 和frequency.
Bless mm～～
[此贴子已经被作者于2012/3/31 10:58:17编辑过]
喉咙痛可以吃 OTC的 acetaminophen 和chloraseptic LOZENGE， 这样宝宝会好受些。
[此贴子已经被作者于2012/4/15 12:53:55编辑过]
请问您用的哪个guideline?
我只能查到750mg PO QD是对于4岁到14岁小孩FDA没有通过的疗法。
[此贴子已经被作者于2012/3/31 23:05:15编辑过]
I am a physician. No offense, but the clinical medicine we practice are not the same as whats in your books. New studies are coming out all the time and multiple studies support the use of once daily dozing. This is called Evidenced based medicine.
This is why we go through residency. If we can learn everything from the text book, then we can all be physicians.
[此贴子已经被作者于2012/4/15 15:11:41编辑过]
I am a physician. The clinical medicine we practice are not the same as your books.
Clinical medicines should be Evidence based medicine. I can only find in guidelines 775 mg daily dosage are adult dosage or for children 12 yrs or older (which is the "b" indicates).
The guidelines we used are American Pediatric Society endorsed guidelines.
I don't know what guidelines physicians use, or they create their own guidelines.
[此贴子已经被作者于2012/4/15 15:14:21编辑过]
Clinical medicines should be Evidence based medicine.
The guidelines we used are American Pediatric Society endorsed guidelines. I don't know what guidelines physicians use, or they create their own guidelines.
You need to do some more research then. Guidelines are changing all the time.
You need to do some more research then. Guidelines are changing all the time.
please show the update then, I am hear to learn.
Multiple studies have shown that one time daily dosing of Amoxcillin is just as effective. It also greatly improves patient compliance. The guidelines may not be changing as quickly. Medicine is a field that's evolving very quickly. By the time you graduate, the guideline might be a lot different.
Studies can be biased.
That is why there are millions of studies but not as many reputable guidelines.
I agree the guideline might be different be there are always updates.
Also one need to take clinical judgments into account as well.
That is way different physicians have different opinions.
Anyway,I am really not here to argue with you.
Life is too short.
have a good one~~
[此贴子已经被作者于2012/4/15 15:36:53编辑过]
★ Sent from iPhone App: i-Reader Huaren Lite 7.52
For those who are still interested in arguing on the clinical evidence of once a day amoxicillin vs. twice a day amoxicillin.
Here is what I found:
http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed/16940830
Treatment of streptococcal pharyngitis with once-daily compared with twice-daily amoxicillin: a noninferiority trial.
Clegg HW, Ryan AG, Dallas SD, Kaplan EL, Johnson DR, Norton HJ, Roddey OF, Martin ES, Swetenburg RL, Koonce EW, Felkner MM, Giftos PM.
Source
Eastover Pediatrics, Charlotte, NC 28204, USA. [email protected]
Abstract
BACKGROUND:
Two relatively small previous studies comparing once-daily amoxicillin with conventional therapy for group A streptococcal (GAS) pharyngitis reported similar rates of bacteriologic success for each treatment group. The purpose of this study was to further evaluate once-daily amoxicillin for GAS pharyngitis in a larger study.
METHODS:
In a single pediatric practice, from October through May for 2 consecutive years (2001-2003), we recruited children 3 to 18 years of age who had symptoms and signs suggestive of GAS pharyngitis. Patients with a positive rapid test for GAS were stratified by weight (<40 kg or >or=40 kg) and then randomly assigned to receive once-daily (750 mg or 1000 mg) or twice-daily (2 doses of 375 mg or 500 mg) amoxicillin for 10 days. We determined bacteriologic failure rates for GAS in the pharynx from subsequent swabs taken at 14 to 21 (visit 2) and 28 to 35 (visit 3) days after treatment initiation. We conducted a randomized, controlled, investigator-blinded, noninferiority trial to evaluate whether amoxicillin given once daily would have a bacteriologic failure rate no worse than that of amoxicillin given twice daily within a prespecified margin of 10%. GAS isolates were characterized to distinguish bacteriologic failures from new acquisitions. Adverse events were described and adherence was evaluated by review of returned daily logs and dosage bottles.
RESULTS:
Of 2139 potential study patients during the 2-year period, we enrolled 652 patients, 326 into each treatment group. Children in the 2 groups were comparable with respect to all demographic and clinical characteristics except that children <40 kg more often presented with rash in each treatment group. At visit 2, failure rates were 20.1% (59 of 294) for the once-daily group and 15.5% (46 of 296) for the twice-daily group (difference, 4.53%; 90% confidence interval [CI], -0.6 to 9.7). At visit 3, failure rates were 2.8% (6 of 216) for the once-daily group and 7.1% (16 of 225) for the twice-daily group (difference, -4.33; 90% CI, -7.7 to -1.0). Gastrointestinal and other adverse events occurred in the once-daily treatment group with a frequency comparable to that in the twice-daily treatment group. Presumed allergic reactions occurred in 0.9% (6 of 635). More than 95% (516 of 541) of patients complied with 10 days of therapy with no significant differences between groups.
CONCLUSIONS:
We conclude that amoxicillin given once daily is not inferior to amoxicillin given twice daily. Gastrointestinal and other events did not occur significantly more often in the once-daily treatment group. From the data in this large, investigator-blinded, controlled study, once-daily amoxicillin appears to be a suitable regimen for treatment of GAS pharyngitis.
I believe by now LZ's child should have already recovered. :)