在官方网站看到一个用 Ivermectin (伊维菌素)治理新冠的三期临床实验报告。好像有一些作用,不知为什么没有继续下去。

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-非圣-
楼主 (文学城)
https://clinicaltrials.gov/ct2/show/results/NCT04646109 例如血氧饱和度,实验组显著高于对照组:

 

20.Secondary Outcome

    Title  Description Time Frame
Changes in Oxygen Saturation (SpO2) Values
In both groups, after the treatment period was completed (first 5 days, primary endpoint), patients were followed up for 5 more days (follow-up period). SpO2 values at the end of 6th (FD1), 8th (FD3) and 10th day (FD5) were also recorded. The end of the 10th day was accepted as the secondary endpoint. While the change in SpO2 values on the 6th, 8th and 10th days was calculated graphically, the change in the SpO2 value at the end of the 10th day (secondary endpoint) with the baseline value was compared statistically (the results were given as p value).
From 6th to the end of 10th day
 Outcome Measure Data  Analysis Population Description [Not Specified]   Control Group Study Group Overall Number of Participants Analyzed Mean (Standard Deviation) Unit of Measure: percentage of peripheral capillary O2 Baseline FD1 FD3 FD5
   
Arm/Group Title
 Arm/Group Description: Patients who were hospitalised with a pre-diagnosis of severe COVID-19 pneumonia and thereafter diagnosis of COVID-19 was also confirmed microbiologically with PCR positivity in respiratory tract samples were included into the study. They were randomized to the control and study group, respectively. Hydroxychloroquine, favipiravir and azithromycin (HFA) standard treatment protocol were given to the control group as recommended in the "COVID-19 (SARS-CoV-2 Infection) Guide" prepared by the Republic of Turkey Ministry of Health.

In addition to HFA treatment, ivermectin 200 micrograms/kg/day (9mg between 36-50 kg, 12mg between 51-65 kg, 15mg between 66-79 kg and 200 micrograms/kg in > 80 kg) in the form of a solution prepared for enteral use was added (HFA+I) to the treatment protocol of the study group's for five days. Blood sample was taken with the first dose of ivermectin and haplotype analysis was performed in ABCB1 and CYP3A4 genes in the whole study group.

Ivermectin: Ivermectin 5mg/5ml solution was manufactured by NEUTEC™ Pharmaceutical Company-Turkey, under "Good Manufacturing Practices" (GMP) certification conditions.

30 30
   
89.67  (5.09) 89.93  (6.51)
92.43  (2.86) 94.54  (2.21)
92.91  (2.71) 94.24  (2.76)
93.00  (3.93) 95.35  (2.72)
 Statistical Analysis 1 Statistical Analysis Overview Comparison Group Selection Comments Type of Statistical Test Comments Statistical Test of Hypothesis P-Value Comments Method Comments
Control Group, Study Group
[Not Specified]
Superiority
[Not Specified]
 
0.03
A p<0.05 value was considered statistically significant
Wilcoxon (Mann-Whitney)
[Not Specified]
v
viewfinder
有正在进行的临床试验

https://activ6study.org/

v
viewfinder
是杜克大学主导、NIH 支持的。牛津大学也在英国做临床试验
f
fuz
大略看了下所监测数据的初步统计分析,撇了撇嘴。例数少,设计粗,结果差,很难成文发表。
c
coinbycoin
Ivermectin 已经治好不少COVID 病人了……HCQ也治好了不少人 但FDA科研文章说不但没用还有害
p
pickshell
是土耳其一所大学搞的试验,病例每组仅30人,且注意看:“Control Group”使用的是Hydroxychloroquine

“Control Group”使用的是“Hydroxychloroquine, favipiravir and azithromycin (HFA)”
而Study Group 是使用的“ In addition to HFA treatment, ivermectin 200 micrograms/kg/day 。。。

从试验设计到结果 总体来说均很差,根本无法继续,夭折不奇怪。。

 

c
coinbycoin
Designed to fail invermectin.
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-非圣-
可能是因为针对重症患者(hospitalised)的缘故。希望能有更多实验针对初期或预防。
f
fuz
请看过LZ贴中引用临试流程和初步结果分析,再来讨论。别人的数据,不能用来证明这个研究
c
coinbycoin
Ivermectin HCQ又便宜又有效,发这些文章的 谁知道是什么人给钱干的,
c
coinbycoin
Timothy 6:10 for the love of money is the root of all evil
p
pickshell
等美国和英国临床试验结果出来,看如何。。
p
pickshell
现在若谁坚信有效,自愿试吃的,可别忘来这汇报结果啊:)