The mechanism of action of hydroxychloroquine/chloroquine against SARS-CoV-2 has yet to be fully elucidated. Chloroquine was first studied in SARS-CoV [30], which was responsible for the 2002–2003 SARS coronavirus epidemic. SARS-CoV shares 79% genetic sequence similarity to SARS-CoV-2, but is thought to result in more severe infection with a case fatality rate of 10% vs. 3% for SARS-CoV-2 [31, 32]. Based on studies initially performed on SARS-CoV, it is believed that SARS-CoV-2 enters cells by binding to the angiotensin-converting enzyme 2 (ACE-2) receptor, and that chloroquine may prevent the virus from binding to this receptor by inhibiting terminal glycosylation [30]. New research has proposed that hydroxychloroquine may additionally prevent SARS-CoV-2 from binding with gangliosides, which in turn may inhibit virion contact with the ACE-2 receptor [33]. Both hydroxychloroquine and chloroquine additionally can incorporate into endosomes and lysosomes, resulting in an increased pH of intracellular compartments. These organelles normally require an acidic environment for homeostasis. Ultimately, this increase in pH results in their dysfunction, leading to defective protein degradation, endocytosis, and exocytosis needed for viral infection, replication, and propagation [34]. Prior work has also demonstrated that coronaviruses can use proteins on the surface of endosomes and endolysosomes for viral entry into host cells [35]. Entry into the endolysosome may be necessary for the viral genome to be released into the cytoplasm of infected host cells [36]. However, it remains unclear how changes in the endosomal environment, particularly changes in pH, may affect the integrity of the SARS-CoV-2 viral genome. Overall, hydroxychloroquine/chloroquine are capable of affecting several cellular pathways and therefore may have several mechanisms of action against SARS-CoV-2.
羟氯喹在治疗COVID-19中的作用，可能跟其调解免疫系统能力有关。所以你就觉得，吃了羟氯喹可以增强免疫能力，减少被病毒感染的机会？错了
不要被民科骗了。COVID-19引起高烧和呼吸困难并导致很多死亡的一种重要原因，是病毒感染诱发细胞因子风暴，细胞因子风暴导致急性炎症，引起多处器官衰竭。细胞因子风暴，本身是免疫过激。羟氯喹，还有很多现在正在试验的药物，属于免疫抑制剂，通过抑制免疫过激来减少细胞因子风暴的危害。
也就是说，没事吃羟氯喹可能会压制免疫反应，从而增加被感染的机会。
医学问题很复杂，你根本不懂药物作用机理，不知道吃了有什么后果就敢吃？
这论坛没有良心为了虚荣自作聪明给别人推销药物的人太坏了。
当然，你的命是你自己的，你爱吃什么吃什么没有人能干涉。但是不要误导别人。
没得新冠吃它可能就是毒药，得了后无症状OR轻症吃它可能还是毒药。但是得了后有比较严重症状+血液里炎症标志偏高后吃它就不可以说它是毒药了。虽然双盲试验没肯定的结论，为了保命医生让你吃一点也未尝不可。LOL
FDA禁止私人诊所医生开药，只有医院才能开药也是为了只给感染症状比较严重的病人吃。没感染的人吃很可能是帮倒忙。FDA做法是对的。LOL
恐惧
平常心，平常心，真能做到就容易了
https://academic.oup.com/ofid/article/7/4/ofaa130/5820538
HYDROXYCHLOROQUINE, CHLOROQUINE, AND SARS-COV-2
The mechanism of action of hydroxychloroquine/chloroquine against SARS-CoV-2 has yet to be fully elucidated. Chloroquine was first studied in SARS-CoV [30], which was responsible for the 2002–2003 SARS coronavirus epidemic. SARS-CoV shares 79% genetic sequence similarity to SARS-CoV-2, but is thought to result in more severe infection with a case fatality rate of 10% vs. 3% for SARS-CoV-2 [31, 32]. Based on studies initially performed on SARS-CoV, it is believed that SARS-CoV-2 enters cells by binding to the angiotensin-converting enzyme 2 (ACE-2) receptor, and that chloroquine may prevent the virus from binding to this receptor by inhibiting terminal glycosylation [30]. New research has proposed that hydroxychloroquine may additionally prevent SARS-CoV-2 from binding with gangliosides, which in turn may inhibit virion contact with the ACE-2 receptor [33]. Both hydroxychloroquine and chloroquine additionally can incorporate into endosomes and lysosomes, resulting in an increased pH of intracellular compartments. These organelles normally require an acidic environment for homeostasis. Ultimately, this increase in pH results in their dysfunction, leading to defective protein degradation, endocytosis, and exocytosis needed for viral infection, replication, and propagation [34]. Prior work has also demonstrated that coronaviruses can use proteins on the surface of endosomes and endolysosomes for viral entry into host cells [35]. Entry into the endolysosome may be necessary for the viral genome to be released into the cytoplasm of infected host cells [36]. However, it remains unclear how changes in the endosomal environment, particularly changes in pH, may affect the integrity of the SARS-CoV-2 viral genome. Overall, hydroxychloroquine/chloroquine are capable of affecting several cellular pathways and therefore may have several mechanisms of action against SARS-CoV-2.
HCQ有蓄积毒性作用，长期、或大剂量服用会引起许多副作用。同意LZ的主张，不适合做为预防用药。
如果有过明确的接触史，和/或出现明显的新冠早期症状，及时按标准量服用HCQ，也许能保你一命。
等到有了肺炎症状，就没啥疗效了。立即去看医生。
药，要用在点子上，否则无效果。
药，还要注意剂量，多了便是毒。
具体用药，参见这个指导
https://www.va.gov/covidtraining/docs/20200618_Dynamic_Drugs_in_the_Battle_of_COVID_19/HCQ_and_CQ_Safety_for_COVID_19_Frequently_Asked_Questions_Amendment_FINAL.pdf
此药用于治疗疟疾，用于治疗自免，它的免疫压制功能是需要的，不属于副作用，是治疗作用；但是，如果没有免疫过激问题，用这个药物则其免疫压制作用本身就可能是有害的。
治疗高血压的药物，能给血压正常甚至血压偏低的人用？
但是说实话别人不爱听，大家都希望有个神药可以保命，所以世间才有如此多的神医骗子
不排除给原来炎症就高的人吃HCQ后可能减弱炎症风暴强度。
野生鱼和野生虾，也常吃。就是对大肉不感兴趣，1、考虑到喂养激素等 2.可能做瑜伽的结果，自然而然不想吃了
以前测过B12，都合格，但这2年没测，想测啥，得说服医生，下次体检会要求。
都是特效药迟迟不见出来，疫苗遥遥无期，医疗资源缺乏惹得祸。 FDA与普通民众所站的思考角度不同。。
FDA当然很谨慎，没有确凿证据是不会松口的，一旦药物吃出问题或死了人，这责任他们担不起。而因新冠死了人他们没责任。
回头想想普通民众心情也不难理解，无奈啊。新冠属于急性传染病又死了那么多人是事实，而特效药又迟迟不见出来，比如NY州政府策略，有症状的自己在家隔离，等到真病重呼吸困难时再去医院救治，吸氧上呼吸机等，谁愿冒这险拖到那个程度？死几个人对整个国家，所谓政客“大局”无足轻重，而对个家庭亲人而言就是条鲜活生命是灾难性悲剧，只得想办法自救咯，一旦被染上指望谁？不自救又怎么办？ 听天由命等死吗？
http://www.fjxiehe.com/yxzc/yxkp/202002/t20200225_9557.htm
自救每个人可以做的事情多了，去锻炼身体啊，这不是根本吗？可是为什么不肯去做非要在这里浪费时间？很奇怪的逻辑
是实在没事，不能去看看书，学点有用的知识？听听音乐陶冶心情不好？为什么怪世界怪别人不怪自己？
那能管用治好病？ 非要等呼吸困难唇脸发紫血氧下降，急诊住院才罢休？死的人还嫌少吗？
拜托，你先去读读美国现在的新冠治疗指南，然后再来讨论好吗？
我说的是官方正规的医疗指导，不是媒体上的噪音。