"This evidence has led to the now widely accepted prion theory, which states that the cellular protein PrP is the sole causative agent of prion diseases; there is no nucleic acid involved. The theory holds that PrP is normally in a stable shape (pN) that does not cause disease. The protein can be flipped, however, into an abnormal shape (pD) that does cause disease. pD is infectious because it can associate with pN and convert it to pD, in an exponential process--each pD can convert more pN to pD.
Protein misfoldding is due to The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis .
实在是噩耗。他还不到五十。身体体质是运动员级别的。我们都不愿接受他最多有一年可活。
我想探索非传统医学途径,希望能有奇迹。
任何人如果有任何信息,可否回复或悄悄话我?
罕见病例,据说各大医院都拒绝收治。
https://patentimages.storage.googleapis.com/54/88/b1/b6c691088ed6ce/CN105194106A.pdf
联系一下 Prion Alliance 的 Eric 和 Sonia,看他们的研究是否开始 Clinical Trial 了?
http://www.prionalliance.org
https://blogs.scientificamerican.com/unofficial-prognosis/three-bizarre-tales-of-medical-survivors-and-what-they-can-and-cannot-teach-us-about-medicine/
菠萝酶,木瓜,这类蛋白酶,多吃点,让朋友自己感觉一下对症状有没有帮助。
还有你这个朋友平常吃的健康吗?
人整个精神断崖似垮,不吃不喝天天睡,每天不说话,呆呆的样子。 到后来过世前,体重才75-80斤,上海三个三甲医院都去看了, 华山医院干脆在那里住下了,当中好多各科医生(脑科,神经科等)几次会诊都没有有效药可治。 小姨过世后,华山 医院想和我姨夫商量可不可以捐遗体做研究,我姨夫和我表弟没答应。
她继承了她母亲的mutation,有研究似乎预计她也会在50左右发病死亡。他们夫妻在研究治疗方法或至少延缓发病时间。 Bless your friend.
https://www.cnn.com/2017/09/19/health/fatal-insomnia-family-curse-somethings-killing-me/index.html
这个三个三甲医院都否定老年痴呆。
"This evidence has led to the now widely accepted prion theory, which states that the cellular protein PrP is the sole causative agent of prion diseases; there is no nucleic acid involved. The theory holds that PrP is normally in a stable shape (pN) that does not cause disease. The protein can be flipped, however, into an abnormal shape (pD) that does cause disease. pD is infectious because it can associate with pN and convert it to pD, in an exponential process--each pD can convert more pN to pD.
(above is from the following URL)
https://www.scientificamerican.com/article/what-is-a-prion-specifica/
只是,什么东西能disrupt 蛋白质?我只知道食物里菠萝酶和木瓜蛋白酶能分解蛋白质,对炎症有好处。。
我觉得楼主的朋友应该试bromelain 。
任何病都有克星。疯牛病是说在八五年发现的,也就是说是一个新病。按照侦探学,这个时间点就是破案节点。我心中有一个想象了。为什么想象?就因为希坡克拉底说过,成为一个医生需要艺术,医疗,命理的综合才能。可见想象力在面对克雅病治疗是多么重要了。光解剖是没法明白克雅病的。
八五年时间发现疯牛病,就是治疗这克雅病的时间节点的破案点
Protein misfoldding is due to The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis .