Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor alpha and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.
作者中有石正丽
估计医生会很快试用的。最好对照Remdesivir做临床试验。
Effects of chloroquine on viral infections: an old drug against today's diseases
https://www.sciencedirect.com/science/article/pii/S1473309903008065?via%3Dihub
Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor alpha and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.
chloroquine: EC50 = 1.13 μM
remdesivir: EC50 = 0.77 μM
对氯喹来说， 人体血液中浓度达到1 μM是不成问题的。（见下面链接）
https://www.ncbi.nlm.nih.gov/pubmed/3501740
“达芦那韦在300微摩尔浓度下，能显著抑制病毒复制”
一般药物在体内不能达到这样的浓度。如果真到了这个浓度，只要是药，人估计是活不成的。
李兰娟心里没数。