Yes, sperm accumulates random mutations as a male ages. This is because sperm cells are continuously produced throughout a man’s life via spermatogenesis, a process involving numerous rounds of cell division. Each time a cell divides, there is a chance of DNA replication errors, leading to mutations.
Key Reasons for Mutation Accumulation in Sperm
1. Continuous Cell Divisions – Unlike eggs, which are formed before birth, sperm undergo ongoing replication. By the time a man reaches 40, his sperm-producing stem cells have undergone hundreds of divisions, increasing the likelihood of mutations.
2. Replication Errors – DNA polymerase, the enzyme responsible for copying DNA, makes occasional errors, some of which are not corrected by repair mechanisms.
3. Oxidative Stress – With aging, increased oxidative stress in the testes can cause DNA damage in sperm.
4. Telomere Shortening – While sperm telomeres tend to lengthen with age, certain genetic stability mechanisms may decline, contributing to mutation risks.
Effects of Accumulated Mutations
• Increased Risk of Genetic Disorders – Older fathers have a higher likelihood of passing on de novo mutations, which can contribute to conditions like autism, schizophrenia, and certain congenital disorders.
• Reduced Sperm Quality – DNA fragmentation and chromosomal abnormalities may increase, potentially affecting fertility.
Conclusion
Yes, sperm accumulates random mutations as men age due to the continuous cell divisions and environmental factors. While many mutations are harmless, some can increase the risk of genetic conditions in offspring.
Yes, sperm accumulates random mutations as a male ages. This is because sperm cells are continuously produced throughout a man’s life via spermatogenesis, a process involving numerous rounds of cell division. Each time a cell divides, there is a chance of DNA replication errors, leading to mutations.
Key Reasons for Mutation Accumulation in Sperm
1. Continuous Cell Divisions – Unlike eggs, which are formed before birth, sperm undergo ongoing replication. By the time a man reaches 40, his sperm-producing stem cells have undergone hundreds of divisions, increasing the likelihood of mutations.
2. Replication Errors – DNA polymerase, the enzyme responsible for copying DNA, makes occasional errors, some of which are not corrected by repair mechanisms.
3. Oxidative Stress – With aging, increased oxidative stress in the testes can cause DNA damage in sperm.
4. Telomere Shortening – While sperm telomeres tend to lengthen with age, certain genetic stability mechanisms may decline, contributing to mutation risks.
Effects of Accumulated Mutations
• Increased Risk of Genetic Disorders – Older fathers have a higher likelihood of passing on de novo mutations, which can contribute to conditions like autism, schizophrenia, and certain congenital disorders.
• Reduced Sperm Quality – DNA fragmentation and chromosomal abnormalities may increase, potentially affecting fertility.
Conclusion
Yes, sperm accumulates random mutations as men age due to the continuous cell divisions and environmental factors. While many mutations are harmless, some can increase the risk of genetic conditions in offspring.
As males age, sperm DNA methylation patterns change, impacting sperm quality and potentially affecting offspring health. DNA methylation is an epigenetic modification where a methyl group (-CH₃) is added to DNA, usually at cytosine bases in CpG sites, regulating gene expression without altering the DNA sequence.
Effects of Aging on Sperm DNA Methylation
1. Global Hypomethylation –
• Older sperm tend to exhibit decreased overall DNA methylation, which can lead to genomic instability and increased mutation rates.
• Hypomethylation in repetitive elements (e.g., LINE-1, Alu) may increase the risk of DNA damage and chromosomal abnormalities.
2. Hypermethylation in Key Genes –
• Certain imprinted genes (e.g., IGF2, H19, MEG3) show hypermethylation, which can disrupt normal embryonic development and increase the risk of imprinting disorders.
• Improper methylation in genes involved in spermatogenesis can reduce sperm production and motility.
3. Oxidative Stress and Methylation Dysregulation –
• Aging leads to increased oxidative stress in the testes, which can interfere with the enzymes responsible for maintaining proper DNA methylation patterns (e.g., DNMTs).
• This results in epigenetic drift, causing variations in methylation patterns that may impair sperm function.
4. Impact on Offspring Health –
• Aberrant sperm DNA methylation has been linked to autism, schizophrenia, congenital disorders, and increased risks of metabolic diseases in children.
• Epigenetic changes in sperm can be heritable, meaning that even if the DNA sequence remains unchanged, abnormal methylation patterns may be passed to offspring.
Conclusion
As males age, sperm DNA methylation becomes less stable, with both hypomethylation (leading to genomic instability) and hypermethylation (affecting key gene regulation). These changes contribute to reduced sperm quality, lower fertility, and increased risks of genetic and developmental disorders in offspring.
是的fetus使就形成了,以后只会减少。详见下面20 weeks: A fetus typically has 6–7
million eggs Birth: A newborn typically has 1–2 million eggs Puberty: A girl typically has 300,000–500,000 eggs。女性成熟的卵子一般400-500左右,因为每个月是随机从众多(这个随年龄减少十几到几十都有可能)选出一个能够成熟。
华大基因的CEO尹烨说基因真正对人类健康，行为（包括经验）有贡献的是还有性能力的老男人。不知道他说这话是有意制造轰动，还是有遗传学上的公认的道理？
Yes, sperm accumulates random mutations as a male ages. This is because sperm cells are continuously produced throughout a man’s life via spermatogenesis, a process involving numerous rounds of cell division. Each time a cell divides, there is a chance of DNA replication errors, leading to mutations.
Key Reasons for Mutation Accumulation in Sperm
1. Continuous Cell Divisions – Unlike eggs, which are formed before birth, sperm undergo ongoing replication. By the time a man reaches 40, his sperm-producing stem cells have undergone hundreds of divisions, increasing the likelihood of mutations.
2. Replication Errors – DNA polymerase, the enzyme responsible for copying DNA, makes occasional errors, some of which are not corrected by repair mechanisms.
3. Oxidative Stress – With aging, increased oxidative stress in the testes can cause DNA damage in sperm.
4. Telomere Shortening – While sperm telomeres tend to lengthen with age, certain genetic stability mechanisms may decline, contributing to mutation risks.
Effects of Accumulated Mutations
• Increased Risk of Genetic Disorders – Older fathers have a higher likelihood of passing on de novo mutations, which can contribute to conditions like autism, schizophrenia, and certain congenital disorders.
• Reduced Sperm Quality – DNA fragmentation and chromosomal abnormalities may increase, potentially affecting fertility.
Conclusion
Yes, sperm accumulates random mutations as men age due to the continuous cell divisions and environmental factors. While many mutations are harmless, some can increase the risk of genetic conditions in offspring.
年轻时候和老了以后，一个人的基因不一样？
脑洞大开
Yes, sperm accumulates random mutations as a male ages. This is because sperm cells are continuously produced throughout a man’s life via spermatogenesis, a process involving numerous rounds of cell division. Each time a cell divides, there is a chance of DNA replication errors, leading to mutations.
Key Reasons for Mutation Accumulation in Sperm
1. Continuous Cell Divisions – Unlike eggs, which are formed before birth, sperm undergo ongoing replication. By the time a man reaches 40, his sperm-producing stem cells have undergone hundreds of divisions, increasing the likelihood of mutations.
2. Replication Errors – DNA polymerase, the enzyme responsible for copying DNA, makes occasional errors, some of which are not corrected by repair mechanisms.
3. Oxidative Stress – With aging, increased oxidative stress in the testes can cause DNA damage in sperm.
4. Telomere Shortening – While sperm telomeres tend to lengthen with age, certain genetic stability mechanisms may decline, contributing to mutation risks.
Effects of Accumulated Mutations
• Increased Risk of Genetic Disorders – Older fathers have a higher likelihood of passing on de novo mutations, which can contribute to conditions like autism, schizophrenia, and certain congenital disorders.
• Reduced Sperm Quality – DNA fragmentation and chromosomal abnormalities may increase, potentially affecting fertility.
Conclusion
Yes, sperm accumulates random mutations as men age due to the continuous cell divisions and environmental factors. While many mutations are harmless, some can increase the risk of genetic conditions in offspring.
As males age, sperm DNA methylation patterns change, impacting sperm quality and potentially affecting offspring health. DNA methylation is an epigenetic modification where a methyl group (-CH₃) is added to DNA, usually at cytosine bases in CpG sites, regulating gene expression without altering the DNA sequence.
Effects of Aging on Sperm DNA Methylation
1. Global Hypomethylation –
• Older sperm tend to exhibit decreased overall DNA methylation, which can lead to genomic instability and increased mutation rates.
• Hypomethylation in repetitive elements (e.g., LINE-1, Alu) may increase the risk of DNA damage and chromosomal abnormalities.
2. Hypermethylation in Key Genes –
• Certain imprinted genes (e.g., IGF2, H19, MEG3) show hypermethylation, which can disrupt normal embryonic development and increase the risk of imprinting disorders.
• Improper methylation in genes involved in spermatogenesis can reduce sperm production and motility.
3. Oxidative Stress and Methylation Dysregulation –
• Aging leads to increased oxidative stress in the testes, which can interfere with the enzymes responsible for maintaining proper DNA methylation patterns (e.g., DNMTs).
• This results in epigenetic drift, causing variations in methylation patterns that may impair sperm function.
4. Impact on Offspring Health –
• Aberrant sperm DNA methylation has been linked to autism, schizophrenia, congenital disorders, and increased risks of metabolic diseases in children.
• Epigenetic changes in sperm can be heritable, meaning that even if the DNA sequence remains unchanged, abnormal methylation patterns may be passed to offspring.
Conclusion
As males age, sperm DNA methylation becomes less stable, with both hypomethylation (leading to genomic instability) and hypermethylation (affecting key gene regulation). These changes contribute to reduced sperm quality, lower fertility, and increased risks of genetic and developmental disorders in offspring.
2011,2012左右有文章研究过父亲年龄对子女的影响,那个study size比较小,但结论是父亲年龄越大,子女有精神疾病和自闭症等发病越高。父亲越年轻,相应的risk越小。
能受精的精子质量一般没有问题
我觉得这个link里面说的比较靠谱，
https://zh.wikipedia.org/wiki/%E7%B2%BE%E5%8E%9F%E7%BB%86%E8%83%9E
所以很伤身体
性卵子质量一定差；如果是，那卵子后期差的原因就是因为放置太久的缘故？
进而影响精子的质量
得老男人肯定身体上的问题也会复制粘贴，对小孩的健康有不好影响。
million eggs Birth: A newborn typically has 1–2 million eggs Puberty: A girl typically has 300,000–500,000 eggs。女性成熟的卵子一般400-500左右,因为每个月是随机从众多(这个随年龄减少十几到几十都有可能)选出一个能够成熟。