FDA： Do not remove your PAXLOVID tablets from the blister card before you are ready to take your dose. ? Take your first dose of PAXLOVID in the Morning or Evening, depending on when you pick up your prescription, or as recommended by your healthcare provider. ? Swallow the tablets whole. Do not chew, break, or crush the tablets. ? Take PAXLOVID with or without food. ? Do not stop taking PAXLOVID without talking to your healthcare provider, even if you feel better. ? If you miss a dose of PAXLOVID within 8 hours of the time it is usually taken, take it as soon as you remember. If you miss a dose by more than 8 hours, skip the missed dose and take the next dose at your regular time. Do not take 2 doses of PAXLOVID at the same time. ? If you take too much PAXLOVID, call your healthcare provider or go to the nearest hospital emergency room right away. ? If you are taking a ritonavir- or cobicistat-containing medicine to treat hepatitis C or Human Immunodeficiency Virus (HIV), you should continue to take your medicine as prescribed by your healthcare provider
很大， 又据说不允许碾成粉末或者剪碎了服用， 请问，是真的吗？
那么怎么吃下去啊？
剪开或者压碎就太不开思议了
我一个朋友是这方面专家，越老越值钱，官越做越大。
药片没有太大呀，正常尺寸偏大一些。吞服应该没问题。
https://www.chemicalbook.com/Search.aspx?keyword=nirmatrelvir
https://www.chemicalbook.com/ProductList.aspx?kwd=ritonavir
用 nanocrystal 或者amorphous技术，可以大大改善药物溶解和吸收。这样制成的药片如果被碾碎或加入液体会返回晶体状态。我估计这是要整粒马上咽下去的原因。
FDA：
Do not remove your PAXLOVID tablets from the blister card before you are ready to take your dose.
? Take your first dose of PAXLOVID in the Morning or Evening, depending on when you pick up your prescription, or as recommended by your healthcare provider.
? Swallow the tablets whole. Do not chew, break, or crush the tablets.
? Take PAXLOVID with or without food.
? Do not stop taking PAXLOVID without talking to your healthcare provider, even if you feel better.
? If you miss a dose of PAXLOVID within 8 hours of the time it is usually taken, take it as soon as you remember. If you miss a dose by more than 8 hours, skip the missed dose and take the next dose at your regular time. Do not take 2 doses of PAXLOVID at the same time.
? If you take too much PAXLOVID, call your healthcare provider or go to the nearest hospital emergency room right away.
? If you are taking a ritonavir- or cobicistat-containing medicine to treat hepatitis C or Human Immunodeficiency Virus (HIV), you should continue to take your medicine as prescribed by your healthcare provider