First, inflammation is driven by high titers of anti-spike IgG, a hallmark of severe disease. Second, we found that anti-spike IgG from patients with severe COVID-19 is intrinsically more pro-inflammatory because of different glycosylation, particularly low fucosylation, of the antibody Fc tail. Notably, low fucosylation of anti-spike IgG was normalized in a few weeks after initial infection with SARS-CoV-2, indicating that the increased antibody-dependent inflammation mainly occurs at the time of seroconversion.这个藻岩糖的问题我见过不少文章提起了。
【 在 atack (小军号) 的大作中提到: 】 : First, inflammation is driven by high titers of anti-spike IgG, a hallmark : of severe disease. Second, we found that anti-spike IgG from patients with : severe COVID-19 is intrinsically more pro-inflammatory because of different : glycosylation, particularly low fucosylation, of the antibody Fc tail. : Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased : antibody-dependent inflammation mainly occurs at the time of seroconversion. : 这个藻岩糖的问题我见过不少文章提起了。
For SARS-CoV-2, there is very little evidence for ADE. Instead, increased pathology by afucosylated IgG in COVID-19 patients likely results from excessive immune activation.
【 在 atack (小军号) 的大作中提到: 】 : First, inflammation is driven by high titers of anti-spike IgG, a hallmark : of severe disease. Second, we found that anti-spike IgG from patients with : severe COVID-19 is intrinsically more pro-inflammatory because of different : glycosylation, particularly low fucosylation, of the antibody Fc tail. : Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased : antibody-dependent inflammation mainly occurs at the time of seroconversion. : 这个藻岩糖的问题我见过不少文章提起了。
【 在 wavelet58 (wavelet58) 的大作中提到: 】 : 英文看不懂，中文总结？ : : First, inflammation is driven by high titers of anti-spike IgG, a : hallmark : : of severe disease. Second, we found that anti-spike IgG from patients : with : : severe COVID-19 is intrinsically more pro-inflammatory because of : different : : glycosylation, particularly low fucosylation, of the antibody Fc tail. : : Notably, low fucosylation of anti-spike IgG was normalized in a few : weeks : ...................
需要有 High titers and low fucosylation， 或者是 Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity (https://science.sciencemag.org/content/371/6532/eabc8378.abstract)
Notably, low fucosylation of anti-spike IgG was normalized in a few weeks after initial infection with SARS-CoV-2, indicating that the increased antibody-dependent inflammation mainly occurs at the time of seroconversion.
【 在 dhuan (heihei) 的大作中提到: 】 : 这文章是疫苗重大利好吧？ : Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased : antibody-dependent inflammation mainly occurs at the time of seroconversion. : 打完疫苗到血清转换的两三个星期如果不感染，之后的抗体就比较成熟了，不会引发炎 : 症反应了。这似乎也和数据中观察到的一致，第一针之后两周内如果感染，病情并不减 : 轻，再往后即使感染，重症也少些。
【 在 dhuan (heihei) 的大作中提到: 】 : 这文章是疫苗重大利好吧？ : Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased : antibody-dependent inflammation mainly occurs at the time of seroconversion. : 打完疫苗到血清转换的两三个星期如果不感染，之后的抗体就比较成熟了，不会引发炎 : 症反应了。这似乎也和数据中观察到的一致，第一针之后两周内如果感染，病情并不减 : 轻，再往后即使感染，重症也少些。
For SARS-CoV-2, there is very little evidence for ADE. Instead, increased pathology by afucosylated IgG in COVID-19 patients likely results from excessive immune activation. To make this difference clear, we propose to not use the term ADE, but instead to use antibody-dependent inflammation ( ADI) to denote antibody-induced pathology as observed in COVID-19 patients.
A screenshot of a tweet shared more than 42,000 times on Instagram falsely claimed that the death rate for fully vaccinated people sick with COVID-19 is “significantly higher” compared to unvaccinated individuals. That’s false.
Public health experts agree that the author of the post likely miscalculated the death rate among fully vaccinated adults. Furthermore, experts say that it is flawed and misleading to use these figures to calculate a death rate and compare it to the unvaccinated population.
The post also claims that more than 7,000 people who have been fully vaccinated have become infected with the virus that causes COVID-19. That’s true — the CDC has actually received more than 9,000 reports of vaccine breakthrough infections.
Breakthrough infections were expected by experts and the makers of the vaccine, but the post deceptively uses this data to give viewers the impression that the vaccine is ineffective and actually dangerous. The lack of context is misleading. 【 在 atack (小军号) 的大作中提到: 】 : 你要往好的方面想当然可以这么说，但事实是接种后死亡率更高。原因可以是接种疫苗 : 的感染病毒后，记忆B细胞快速生成许多新抗体，这些新抗体极有可能也是低岩藻糖化 : 的。 : seroconversion.
就这篇文章：We found evidence that, although dissemination of the P.1 variant led to increases in reported COVID-19 death at all ages, the proportion of deaths among the elderly started to fall rapidly from the second half of February 2021. This proportion had been stable at around 25%-30% since the beginning of the epidemic in early 2020, but is now below 15% in April 2021.
The most likely explanation for the observed reductions in proportionate mortality and in rate ratios for the elderly is the rapid increase in immunization coverage in these age groups, as has been described for other parts of the world.
【 在 goldenfly (我家小月) 的大作中提到: 】 : 你自己断章取义的想法吧 : http://www.medrxiv.org/content/10.1101/2021.04.27.21256187v1 : 巴西80岁以上的老人三月初90%以上的接种疫苗，一个月后死亡人数翻倍，二者的时间 : 相关性充分说明了新冠疫苗不仅不能降低新冠死亡，反而会因为ADE加重死亡。 : 就这篇文章：We found evidence that, although dissemination of the P.1 : variant led to increases in reported COVID-19 death at all ages, the : proportion of deaths among the elderly started to fall rapidly from the : second half of February 2021. This proportion had been stable at around 25%- : 30% since the beginning of the epidemic in early 2020, but is now below 15% : in April 2021. : ...................
PATIENT HISTORIES Patient 1 was a healthy 51-year-old woman with no risk factors for severe Covid-19 who received the first dose of mRNA-1273 vaccine on January 21, 2021, and the second dose on February 19. She had adhered strictly to routine precautions. Ten hours after she received the second vaccine dose, flulike muscle aches developed. These symptoms resolved the following day. On March 10 (19 days after she received the second vaccine dose), a sore throat, congestion, and headache developed, and she tested positive for SARS-CoV-2 RNA at Rockefeller University later that day. On March 11, she lost her sense of smell. Her symptoms gradually resolved over a 1-week period.
Patient 2 was a healthy 65-year-old woman with no risk factors for severe Covid-19 who received the first dose of BNT162b2 vaccine on January 19 and the second dose on February 9. Pain that developed in the inoculated arm lasted for 2 days. On March 3, her unvaccinated partner tested positive for SARS-CoV-2, and on March 16, fatigue, sinus congestion, and a headache developed in Patient 2. On March 17, she felt worse and tested positive for SARS-CoV-2 RNA, 36 days after completing vaccination. Her symptoms plateaued and began to resolve on March 20.
【 在 goldenfly (我家小月) 的大作中提到: 】 : 你应该看看真实世界：打了疫苗之后再感染， : 其中一个一个星期恢复， : 一个三天就恢复了。 : Vaccine Breakthrough Infections with SARS-CoV-2 Variants : https://www.nejm.org/doi/full/10.1056/NEJMoa2105000 : PATIENT HISTORIES : Patient 1 was a healthy 51-year-old woman with no risk factors for severe : Covid-19 who received the first dose of mRNA-1273 vaccine on January 21, : 2021, and the second dose on February 19. She had adhered strictly to : routine precautions. Ten hours after she received the second vaccine dose, : ...................
【 在 atack (小军号) 的大作中提到: 】 : 标 题: 确认体内ADE的文章终于发出来了 : 发信站: BBS 未名空间站 (Wed May 12 09:28:01 2021, 美东) : : First, inflammation is driven by high titers of anti-spike IgG, a hallmark : of severe disease. Second, we found that anti-spike IgG from patients with : severe COVID-19 is intrinsically more pro-inflammatory because of different : glycosylation, particularly low fucosylation, of the antibody Fc tail. : Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased : antibody-dependent inflammation mainly occurs at the time of seroconversion. : 这个藻岩糖的问题我见过不少文章提起了。 : : --
非常经典的抗体的尾端激发巨噬细胞造成严重炎症反应。
http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
这篇文章其实去年7月份就预印了，但明显有人压着不让发。
一直在等你的新文献
【 在 atack (小军号) 的大作中提到: 】
: http://stm.sciencemag.org/content/early/2021/05/10/scitranslmed.abf8654
: 非常经典的抗体的尾端激发巨噬细胞造成严重炎症反应。
: http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
: 这篇文章其实去年7月份就预印了，但明显有人压着不让发。
First, inflammation is driven by high titers of anti-spike IgG, a hallmark
of severe disease. Second, we found that anti-spike IgG from patients with
severe COVID-19 is intrinsically more pro-inflammatory because of different glycosylation, particularly low fucosylation, of the antibody Fc tail.
Notably, low fucosylation of anti-spike IgG was normalized in a few weeks
after initial infection with SARS-CoV-2, indicating that the increased
antibody-dependent inflammation mainly occurs at the time of seroconversion.这个藻岩糖的问题我见过不少文章提起了。
小军号加油
【 在 atack (小军号) 的大作中提到: 】
: First, inflammation is driven by high titers of anti-spike IgG, a hallmark
: of severe disease. Second, we found that anti-spike IgG from patients with
: severe COVID-19 is intrinsically more pro-inflammatory because of
different
: glycosylation, particularly low fucosylation, of the antibody Fc tail.
: Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased
: antibody-dependent inflammation mainly occurs at the time of
seroconversion.
: 这个藻岩糖的问题我见过不少文章提起了。
英文看不懂，中文总结？
【 在 atack(小军号) 的大作中提到: 】
: First, inflammation is driven by high titers of anti-spike IgG, a
hallmark
: of severe disease. Second, we found that anti-spike IgG from patients with
: severe COVID-19 is intrinsically more pro-inflammatory because of
different
: glycosylation, particularly low fucosylation, of the antibody Fc tail.
: Notably, low fucosylation of anti-spike IgG was normalized in a few
weeks
: after initial infection with SARS-CoV-2, indicating that the increased
: antibody-dependent inflammation mainly occurs at the time of
seroconversion.
: 这个藻岩糖的问题我见过不少文章提起了。
For SARS-CoV-2, there is very little evidence for ADE. Instead, increased
pathology by afucosylated IgG in COVID-19 patients likely results from
excessive immune activation.
【 在 atack (小军号) 的大作中提到: 】
: First, inflammation is driven by high titers of anti-spike IgG, a hallmark
: of severe disease. Second, we found that anti-spike IgG from patients with
: severe COVID-19 is intrinsically more pro-inflammatory because of
different
: glycosylation, particularly low fucosylation, of the antibody Fc tail.
: Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased
: antibody-dependent inflammation mainly occurs at the time of
seroconversion.
: 这个藻岩糖的问题我见过不少文章提起了。
尼玛，天天ADE.前两个月你也天天黑以色列吧。现在不提以色列了？
简单的说就是突刺蛋白抗体滴度越高，肺部病情越重。抗体的尾巴如果没有足够的藻岩糖化会导致和巨噬细胞的亲和力大增，激活巨噬细胞释放炎症因子而加重病情。
【 在 wavelet58 (wavelet58) 的大作中提到: 】
: 英文看不懂，中文总结？
:
: First, inflammation is driven by high titers of anti-spike IgG, a
: hallmark
:
: of severe disease. Second, we found that anti-spike IgG from
patients
: with
:
: severe COVID-19 is intrinsically more pro-inflammatory because of
: different
:
: glycosylation, particularly low fucosylation, of the antibody Fc
tail.
:
: Notably, low fucosylation of anti-spike IgG was normalized in a few : weeks
: ...................
我最近也发了不少以色列的吧？以色列的疫情比去年同期严重多了，下个月就会掉头向上。
【 在 localdisk (与世无争) 的大作中提到: 】
: 尼玛，天天ADE.前两个月你也天天黑以色列吧。现在不提以色列了？
谢谢翻译，原文里太多的单词不认识了，隔行如隔山啊
【 在 atack (小军号) 的大作中提到: 】
: 简单的说就是突刺蛋白抗体滴度越高，肺部病情越重。抗体的尾巴如果没有足够的藻岩
: 糖化会导致和巨噬细胞的亲和力大增，激活巨噬细胞释放炎症因子而加重病情。
: patients
: tail.
借你吉言，God damn Israel!
【 在 atack (小军号) 的大作中提到: 】
: 我最近也发了不少以色列的吧？以色列的疫情比去年同期严重多了，下个月就会掉头向
: 上。
直播吃屎吗?
【 在 atack (小军号) 的大作中提到: 】
: 我最近也发了不少以色列的吧？以色列的疫情比去年同期严重多了，下个月就会掉头向
: 上。
为什么去年5月份以色列也是几乎没有case，不科学啊
【 在 atack (小军号) 的大作中提到: 】
: 我最近也发了不少以色列的吧？以色列的疫情比去年同期严重多了，下个月就会掉头向
: 上。
那疫苗还是不打好，对吗？
【 在 atack(小军号) 的大作中提到: 】
: 简单的说就是突刺蛋白抗体滴度越高，肺部病情越重。抗体的尾巴如果没有足够的藻岩
: 糖化会导致和巨噬细胞的亲和力大增，激活巨噬细胞释放炎症因子而加重病情。
: patients
: tail.
mRNA的也会？
[在 atack (小军号) 的大作中提到：]
:我最近也发了不少以色列的吧？以色列的疫情比去年同期严重多了，下个月就会掉头
向上。
需要有 High titers and low fucosylation， 或者是 Afucosylated IgG
characterizes enveloped viral responses and correlates with COVID-19
severity (https://science.sciencemag.org/content/371/6532/eabc8378.abstract)
你怎么知道新冠的康复者，疫苗接种的人具有的抗体是 low fucosylation， 或者是
Afucosylated
【 在 atack (小军号) 的大作中提到: 】
: http://stm.sciencemag.org/content/early/2021/05/10/scitranslmed.abf8654
: 非常经典的抗体的尾端激发巨噬细胞造成严重炎症反应。
: http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
: 这篇文章其实去年7月份就预印了，但明显有人压着不让发。
这文章是疫苗重大利好吧？
Notably, low fucosylation of anti-spike IgG was normalized in a few weeks
after initial infection with SARS-CoV-2, indicating that the increased
antibody-dependent inflammation mainly occurs at the time of seroconversion.
打完疫苗到血清转换的两三个星期如果不感染，之后的抗体就比较成熟了，不会引发炎症反应了。这似乎也和数据中观察到的一致，第一针之后两周内如果感染，病情并不减轻，再往后即使感染，重症也少些。
【 在 atack (小军号) 的大作中提到: 】
: http://stm.sciencemag.org/content/early/2021/05/10/scitranslmed.abf8654
: 非常经典的抗体的尾端激发巨噬细胞造成严重炎症反应。
: http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
: 这篇文章其实去年7月份就预印了，但明显有人压着不让发。
打了疫苗，不就是刺激突刺蛋白抗体的产生吗？ 这么说会起反作用 ？
不明觉厉的dry bench.
【 在 atack (小军号) 的大作中提到: 】
: 简单的说就是突刺蛋白抗体滴度越高，肺部病情越重。抗体的尾巴如果没有足够的藻岩
: 糖化会导致和巨噬细胞的亲和力大增，激活巨噬细胞释放炎症因子而加重病情。
: patients
: tail.
非常同意你的分析。
【 在 dhuan (heihei) 的大作中提到: 】
: 这文章是疫苗重大利好吧？
: Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased
: antibody-dependent inflammation mainly occurs at the time of
seroconversion.
: 打完疫苗到血清转换的两三个星期如果不感染，之后的抗体就比较成熟了，不会引发炎
: 症反应了。这似乎也和数据中观察到的一致，第一针之后两周内如果感染，病情并不减
: 轻，再往后即使感染，重症也少些。
你要往好的方面想当然可以这么说，但事实是接种后死亡率更高。原因可以是接种疫苗的感染病毒后，记忆B细胞快速生成许多新抗体，这些新抗体极有可能也是低岩藻糖化
的。
【 在 dhuan (heihei) 的大作中提到: 】
: 这文章是疫苗重大利好吧？
: Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased
: antibody-dependent inflammation mainly occurs at the time of
seroconversion.
: 打完疫苗到血清转换的两三个星期如果不感染，之后的抗体就比较成熟了，不会引发炎
: 症反应了。这似乎也和数据中观察到的一致，第一针之后两周内如果感染，病情并不减
: 轻，再往后即使感染，重症也少些。
竟然有个外f叫薛蛮子
你这个接种后死亡率更高不是事实，只能说“接种后如果感染死亡率比没接种感染没有明显变化”。
现在的数据比较乱，还不能给明确的结论。CDC数据：
到4月27日，美国有9500万完成接种，9245人感染，2525人无症状，835人住院，132人
死亡。
当然现在follow-up还太短。
【 在 atack (小军号) 的大作中提到: 】
: 你要往好的方面想当然可以这么说，但事实是接种后死亡率更高。原因可以是接种疫苗
: 的感染病毒后，记忆B细胞快速生成许多新抗体，这些新抗体极有可能也是低岩藻糖化
: 的。
: seroconversion.
For SARS-CoV-2, there is very little evidence for ADE. Instead, increased
pathology by afucosylated IgG in COVID-19 patients likely results from
excessive immune activation. To make this difference clear, we propose to
not use the term ADE, but instead to use antibody-dependent inflammation (
ADI) to denote antibody-induced pathology as observed in COVID-19 patients.
请列出数据来证明！
【 在 atack (小军号) 的大作中提到: 】
: 你要往好的方面想当然可以这么说，但事实是接种后死亡率更高。原因可以是接种疫苗
: 的感染病毒后，记忆B细胞快速生成许多新抗体，这些新抗体极有可能也是低岩藻糖化
: 的。
: seroconversion.
No, The Death Rate For Vaccinated People Is Not Higher Than That Of
Unvaccinated People
https://www.capradio.org/articles/2021/05/10/no-the-death-rate-for-
vaccinated-people-is-not-higher-than-that-of-unvaccinated-people/
If your time is short:
A screenshot of a tweet shared more than 42,000 times on Instagram falsely
claimed that the death rate for fully vaccinated people sick with COVID-19
is “significantly higher” compared to unvaccinated individuals. That’s
false.
Public health experts agree that the author of the post likely miscalculated the death rate among fully vaccinated adults. Furthermore, experts say that it is flawed and misleading to use these figures to calculate a death rate and compare it to the unvaccinated population.
The post also claims that more than 7,000 people who have been fully
vaccinated have become infected with the virus that causes COVID-19. That’s true — the CDC has actually received more than 9,000 reports of vaccine
breakthrough infections.
Breakthrough infections were expected by experts and the makers of the
vaccine, but the post deceptively uses this data to give viewers the
impression that the vaccine is ineffective and actually dangerous. The lack of context is misleading.
【 在 atack (小军号) 的大作中提到: 】
: 你要往好的方面想当然可以这么说，但事实是接种后死亡率更高。原因可以是接种疫苗
: 的感染病毒后，记忆B细胞快速生成许多新抗体，这些新抗体极有可能也是低岩藻糖化
: 的。
: seroconversion.
巴西80岁以上的老人三月初90%以上的接种疫苗，一个月后死亡人数翻倍，二者的时间
相关性充分说明了新冠疫苗不仅不能降低新冠死亡，反而会因为ADE加重死亡。
以色列的数据显示新冠疫苗提高死亡率5倍http://www.mitbbs.com/article_t/Military/60020601.html
匈牙利接种新冠疫苗染病后的死亡率是273／5714=4.8%，有的疫苗接种染病后的死亡率奇高，比如摩德纳的疫苗接种染病后的死亡率是12／108=11%。当然这个数据样本不大
，年龄分布有可能偏高。
匈牙利新冠死亡率是26625／770000=3.5%http://hungarytoday.hu/hungary-vaccines-vaccine-effectiveness-inoculation-vaccine-effectiveness-comparison-pfizer-sputnik-sinopharm/
【 在 goldenfly (我家小月) 的大作中提到: 】
: 请列出数据来证明！
因果确立很困难的。
这种文章有可能是把因果搞反了。
抗体水平高导致重症还是重症导致抗体水平高。
1.4%的死亡率，9%的住院率可不低，尤其是随着时间死亡率会上升。
【 在 dhuan (heihei) 的大作中提到: 】
: 你这个接种后死亡率更高不是事实，只能说“接种后如果感染死亡率比没接种感染没有
: 明显变化”。
: 现在的数据比较乱，还不能给明确的结论。CDC数据：
: 到4月27日，美国有9500万完成接种，9245人感染，2525人无症状，835人住院，132人
: 死亡。
: 当然现在follow-up还太短。
你自己断章取义的想法吧
http://www.medrxiv.org/content/10.1101/2021.04.27.21256187v1
巴西80岁以上的老人三月初90%以上的接种疫苗，一个月后死亡人数翻倍，二者的时间
相关性充分说明了新冠疫苗不仅不能降低新冠死亡，反而会因为ADE加重死亡。
就这篇文章：We found evidence that, although dissemination of the P.1
variant led to increases in reported COVID-19 death at all ages, the
proportion of deaths among the elderly started to fall rapidly from the
second half of February 2021. This proportion had been stable at around 25%-30% since the beginning of the epidemic in early 2020, but is now below 15% in April 2021.
The most likely explanation for the observed reductions in proportionate
mortality and in rate ratios for the elderly is the rapid increase in
immunization coverage in these age groups, as has been described for other
parts of the world.
匈牙利以色列的数据你大笔一挥，就算了出来，
【 在 atack (小军号) 的大作中提到: 】
: http://www.medrxiv.org/content/10.1101/2021.04.27.21256187v1
: 巴西80岁以上的老人三月初90%以上的接种疫苗，一个月后死亡人数翻倍，二者的时间
: 相关性充分说明了新冠疫苗不仅不能降低新冠死亡，反而会因为ADE加重死亡。
: 以色列的数据显示新冠疫苗提高死亡率5倍
: http://www.mitbbs.com/article_t/Military/60020601.html
: 匈牙利接种新冠疫苗染病后的死亡率是273／5714=4.8%，有的疫苗接种染病后的死亡率
: 奇高，比如摩德纳的疫苗接种染病后的死亡率是12／108=11%。当然这个数据样本不大
: ，年龄分布有可能偏高。
: 匈牙利新冠死亡率是26625／770000=3.5%
: http://hungarytoday.hu/hungary-vaccines-vaccine-effectiveness-inoculation-vaccine-effectiveness-comparison-pfizer-sputnik-sinopharm/
作者在避讳而已，ADE或者ADP的文章多了。
http://www.medrxiv.org/content/10.1101/2020.10.08.20209114v1.full
(这篇文章报道8%的轻症病人,76%的重症病人的血清呈现ADE).
http://www.biorxiv.org/content/10.1101/2021.02.22.432407v1
(这篇文章报道了新冠非中和IgG抗体帮助病毒杀死巨噬细胞，我认为也是通过FcγR，
而不是作者猜想的诱发了巨噬细胞的ACE2表达后再通过ACE2感染)。
http://www.medrxiv.org/content/10.1101/2021.03.06.21252796v1
(这篇文章报道了突刺蛋白抗体（单抗／恢复病人血清）帮助新冠病毒感染本来无法感
染的单核细胞。单核细胞是重要的先天免疫系统的哨兵，它被新冠病毒感染后释放警戒信号引发了炎症风暴).
http://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
(这个文章用灭活新冠疫苗在雪貂上观察到了ADE，还好不严重，不过确实了新冠灭活疫苗会加重肺部病情。实验中观察到了接种组的雪貂普遍有肝炎，而肝炎是典型的ADE，
但作者说肝炎很常见，与疫苗无关).
http://www.biorxiv.org/content/10.1101/2020.12.18.423358v1
(这篇文章从重症新冠病人分离出可以急剧增强感染的新冠抗体.可以说是一种ADE).
http://www.biorxiv.org/content/10.1101/2020.07.26.222257v1
(这篇文章报道了新冠ADE通过FcγRIIB诱发，并验证了抗体Fc变异可以消除ADE).
http://www.biorxiv.org/content/10.1101/2020.12.31.424729v1
(这篇文章报道了新冠抗体因为Fc端糖基化引起ADE)
http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
(这篇文章常被用来说上面在体外观察的ADE不代表体内，但这篇文章其实还是观察到了ADE，好消息是比率只有3%).
http://www.biorxiv.org/content/10.1101/2020.12.22.423940v1
(这篇文章常被用来否定ADE，但是这篇文章只试验了巨噬细胞，只观察到病毒没有在巨噬细胞里繁殖。后来别的文章观察到抗体会帮助病毒导致巨噬细胞死亡).
【 在 sayuri (sayuri) 的大作中提到: 】
: For SARS-CoV-2, there is very little evidence for ADE. Instead, increased : pathology by afucosylated IgG in COVID-19 patients likely results from
: excessive immune activation. To make this difference clear, we propose to : not use the term ADE, but instead to use antibody-dependent inflammation (: ADI) to denote antibody-induced pathology as observed in COVID-19 patients.
上面是我对巴西文章的分析。
【 在 goldenfly (我家小月) 的大作中提到: 】
: 你自己断章取义的想法吧
: http://www.medrxiv.org/content/10.1101/2021.04.27.21256187v1
: 巴西80岁以上的老人三月初90%以上的接种疫苗，一个月后死亡人数翻倍，二者的时间
: 相关性充分说明了新冠疫苗不仅不能降低新冠死亡，反而会因为ADE加重死亡。
: 就这篇文章：We found evidence that, although dissemination of the P.1
: variant led to increases in reported COVID-19 death at all ages, the
: proportion of deaths among the elderly started to fall rapidly from the
: second half of February 2021. This proportion had been stable at around 25%-
: 30% since the beginning of the epidemic in early 2020, but is now below 15%
: in April 2021.
: ...................
你应该看看真实世界：打了疫苗之后再感染，
其中一个一个星期恢复，
一个三天就开始恢复了。
病程中症状都很轻。
Vaccine Breakthrough Infections with SARS-CoV-2 Variantshttps://www.nejm.org/doi/full/10.1056/NEJMoa2105000
PATIENT HISTORIES
Patient 1 was a healthy 51-year-old woman with no risk factors for severe
Covid-19 who received the first dose of mRNA-1273 vaccine on January 21,
2021, and the second dose on February 19. She had adhered strictly to
routine precautions. Ten hours after she received the second vaccine dose,
flulike muscle aches developed. These symptoms resolved the following day.
On March 10 (19 days after she received the second vaccine dose), a sore
throat, congestion, and headache developed, and she tested positive for SARS-CoV-2 RNA at Rockefeller University later that day. On March 11, she lost
her sense of smell. Her symptoms gradually resolved over a 1-week period.
Patient 2 was a healthy 65-year-old woman with no risk factors for severe
Covid-19 who received the first dose of BNT162b2 vaccine on January 19 and
the second dose on February 9. Pain that developed in the inoculated arm
lasted for 2 days. On March 3, her unvaccinated partner tested positive for SARS-CoV-2, and on March 16, fatigue, sinus congestion, and a headache
developed in Patient 2. On March 17, she felt worse and tested positive for SARS-CoV-2 RNA, 36 days after completing vaccination. Her symptoms plateaued and began to resolve on March 20.
【 在 atack (小军号) 的大作中提到: 】
: 1.4%的死亡率，9%的住院率可不低，尤其是随着时间死亡率会上升。
特例我也会举，骗人而已。
【 在 goldenfly (我家小月) 的大作中提到: 】
: 你应该看看真实世界：打了疫苗之后再感染，
: 其中一个一个星期恢复，
: 一个三天就恢复了。
: Vaccine Breakthrough Infections with SARS-CoV-2 Variants
: https://www.nejm.org/doi/full/10.1056/NEJMoa2105000
: PATIENT HISTORIES
: Patient 1 was a healthy 51-year-old woman with no risk factors for severe : Covid-19 who received the first dose of mRNA-1273 vaccine on January 21,
: 2021, and the second dose on February 19. She had adhered strictly to
: routine precautions. Ten hours after she received the second vaccine dose,
: ...................
你这就神叨叨了吧
【 在 atack (小军号) 的大作中提到: 】
: 特例我也会举，骗人而已。
没搞过学术半吊子以为铅字印出来的就是真理，其实这些只是讨论，离“定论”还差十万八千里，无非是提出了一个与自己的数据不悖离的假说，事实上任何数据都可以提出很多不同的假说，看你觉得哪款更轰动你就往哪方面靠过去
这里normalize是啥意思？
是想说became normal吗？
把normalize的通用含义放在这里，根本不通
盹盹盹
【 在 atack (小军号) 的大作中提到: 】
: 标 题: 确认体内ADE的文章终于发出来了
: 发信站: BBS 未名空间站 (Wed May 12 09:28:01 2021, 美东)
:
: First, inflammation is driven by high titers of anti-spike IgG, a hallmark
: of severe disease. Second, we found that anti-spike IgG from patients with
: severe COVID-19 is intrinsically more pro-inflammatory because of
different
: glycosylation, particularly low fucosylation, of the antibody Fc tail.
: Notably, low fucosylation of anti-spike IgG was normalized in a few weeks : after initial infection with SARS-CoV-2, indicating that the increased
: antibody-dependent inflammation mainly occurs at the time of
seroconversion.
: 这个藻岩糖的问题我见过不少文章提起了。
:
: --
卧槽，学术界那么恐怖啊。生物医药这种性命攸关的东西居然把没有“定论”，正反都能说的通的东西直接用于全人类...
【 在 jumbo (一生宿便) 的大作中提到: 】
: 没搞过学术半吊子以为铅字印出来的就是真理，其实这些只是讨论，离“定论”还差十
: 万八千里，无非是提出了一个与自己的数据不悖离的假说，事实上任何数据都可以提出
: 很多不同的假说，看你觉得哪款更轰动你就往哪方面靠过去
同学醒醒，疫苗有效是有定论的，ADE是尚无定论的
【 在 wwang308 (ozil) 的大作中提到: 】
: 卧槽，学术界那么恐怖啊。生物医药这种性命攸关的东西居然把没有“定论”，正反都
: 能说的通的东西直接用于全人类...
有效全世界都知道，现在不是在谈有没有“毒”吗？学术界连有没有“毒”都不知道就让大家打？
我一直比较好奇，这么好的技术（有效率实实在在是很高的）居然10多年没上过一次人体实验。
【 在 jumbo (一生宿便) 的大作中提到: 】
: 同学醒醒，疫苗有效是有定论的，ADE是尚无定论的
17000又大摇大摆出来现眼了，lol
[在 wangyangming (灭明功臣) 的大作中提到：]
:一直在等你的新文献
美国感染死亡数字断崖式下降
小军号心急如焚
【 在 atack (小军号) 的大作中提到: 】
: http://stm.sciencemag.org/content/early/2021/05/10/scitranslmed.abf8654
: 非常经典的抗体的尾端激发巨噬细胞造成严重炎症反应。
:
: http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
: 这篇文章其实去年7月份就预印了，但明显有人压着不让发。
在疫苗接种者体内，这个memory B 细胞产生抗体得fucosylation需要多长时间？
【 在 atack (小军号) 的大作中提到: 】
: 你要往好的方面想当然可以这么说，但事实是接种后死亡率更高。原因可以是接种疫苗
: 的感染病毒后，记忆B细胞快速生成许多新抗体，这些新抗体极有可能也是低岩藻糖化
: 的。
: seroconversion.
【 在 atack (小军号) 的大作中提到: 】
: http://stm.sciencemag.org/content/early/2021/05/10/scitranslmed.abf8654
: 非常经典的抗体的尾端激发巨噬细胞造成严重炎症反应。
: http://www.biorxiv.org/content/10.1101/2020.07.13.190140v1
: 这篇文章其实去年7月份就预印了，但明显有人压着不让发。
有意思了，
小军号说对了，你直播吃屎吗？
如果你直播吃屎，我赞成你约他吃屎
【 在 LiYaoshi (药师——非著名中将) 的大作中提到: 】
: 直播吃屎吗?
阳明点，你又出来了。是不是看到美股熔断的希望在即？
【 在 wangyangming (灭明功臣) 的大作中提到: 】
: 一直在等你的新文献
这个文章其实有失偏薄，低藻岩糖的抗体能引起更强的ADCC作用，虽然巨噬细胞炎症因子增强，但是局部引起机体反应的一个trigger，后续的NK，T细胞应答才是杀死感染的细胞
的关键因素，作者故意放大局部而忽视全局的反应，是惯用的提高文章影响因子的手段。另外也不是压着不发，好的杂志要求更多的证据来支持你的理论，一个文章修改一二年很常见