Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection.
Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types.
Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms.
Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders. https://www.nature.com/articles/s41421-021-00329-3
【 在 potassium (镇) 的大作中提到: 】 : 这里有篇类似的，貌似灭活疫苗也不靠谱。 : Here, we report, besides generation of neutralizing antibodies, consistent : alterations in hemoglobin A1c, serum sodium and potassium levels, : coagulation profiles, and renal functions in healthy volunteers after : vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also : been reported in COVID-19 patients, suggesting that vaccination mimicked an : infection. : Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear : cells (PBMCs) before and 28 days after the first inoculation also revealed : consistent alterations in gene expression of many different immune cell : ...................
Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study)
"SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J
Recombination In Vitro - PubMed"
https://pubmed.ncbi.nlm.nih.gov/34696485/
意思是这个蛋白可以修复、可以治病？
意思是全长S protein跟hiv有差不多的能力破坏免疫系统。
用的灭活疫苗下的结论。
尼玛这下子只有NVAX有希望了。
【 在 zhaojing36 (赵景龙) 的大作中提到: 】
: 意思是这个蛋白可以修复、可以治病？
啥意思，展开说说
【 在 RaoYing (老赵走好) 的大作中提到: 】
: 意思是全长S protein跟hiv有差不多的能力破坏免疫系统。
: 用的灭活疫苗下的结论。
: 尼玛这下子只有NVAX有希望了。
这里有篇类似的，貌似灭活疫苗也不靠谱。
Here, we report, besides generation of neutralizing antibodies, consistent
alterations in hemoglobin A1c, serum sodium and potassium levels,
coagulation profiles, and renal functions in healthy volunteers after
vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection.
Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear
cells (PBMCs) before and 28 days after the first inoculation also revealed
consistent alterations in gene expression of many different immune cell
types.
Reduction of CD8+ T cells and increase in classic monocyte contents were
exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and
reduced type I interferon responses, which were confirmed by biological
assays and also had been reported to occur after SARS-CoV-2 infection with
aggravating symptoms.
Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte
imbalances, renal dysfunction, and coagulation disorders.
https://www.nature.com/articles/s41421-021-00329-3
【 在 RaoYing (老赵走好) 的大作中提到: 】
: 意思是全长S protein跟hiv有差不多的能力破坏免疫系统。
: 用的灭活疫苗下的结论。
: 尼玛这下子只有NVAX有希望了。
灭活, 腺病毒和mRNA都是用的裸体全长S protein，
按这个文章说会损坏adaptive immunity。
Novavax那个particle经过包装处理的，至少看报告是能促生CD8+ T cells，http://www.nature.com/articles/s41467-020-20653-8
这个东西就是adaptive immunity中介。
当然本人不是搞这行的，门外汉看个热闹。
【 在 jkerry (Jake) 的大作中提到: 】
: 啥意思，展开说说
是的，最近风向好像都集中在这个CD8, adaptive immunology.
总的看，老子早早提出的疫苗摧毁免疫系统真的不幸应验了。
【 在 potassium (镇) 的大作中提到: 】
: 这里有篇类似的，貌似灭活疫苗也不靠谱。
: Here, we report, besides generation of neutralizing antibodies, consistent
: alterations in hemoglobin A1c, serum sodium and potassium levels,
: coagulation profiles, and renal functions in healthy volunteers after
: vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had
also
: been reported in COVID-19 patients, suggesting that vaccination mimicked an
: infection.
: Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear
: cells (PBMCs) before and 28 days after the first inoculation also revealed
: consistent alterations in gene expression of many different immune cell
: ...................