回复 1楼yutongwwu的帖子 https://www.nejm.org/doi/full/10.1056/NEJMoa2201445 The most recent trial with Dorstalimab is very impressive with dMMR mutation bearing rectal cancer patients (100% complete response, no need for surgery). I would highly recommend you reach out to the study team at Memorial Sloan Kettering Cancer Center: Dr. Cercek can be contacted at [email protected] or at Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065. Dr. Diaz can be contacted at [email protected] or at Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065.
回复 1楼yutongwwu的帖子 https://www.nejm.org/doi/full/10.1056/NEJMoa2201445 The most recent trial with Dorstalimab is very impressive with dMMR mutation bearing rectal cancer patients (100% complete response, no need for surgery). I would highly recommend you reach out to the study team at Memorial Sloan Kettering Cancer Center: Dr. Cercek can be contacted at [email protected] or at Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065. Dr. Diaz can be contacted at [email protected] or at Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065. Margo 发表于 2022-08-10 22:16
Big big bless! 希望楼主能早日康复。 不知道能不能找找这个新闻里的医生，实验组的病人都痊愈了。 https://www.npr.org/2022/06/07/1103545361/cancer-drug-experimental-rectal-chemotherapy-surgery-treatment-immunotherapy 下面是部分内容，A tiny group of people with rectal cancer just experienced something of a scientific miracle: their cancer simply vanished after an experimental treatment. In a very small trial done by doctors at New York's Memorial Sloan Kettering Cancer Center, patients took a drug called dostarlimab for six months. The trial resulted in every single one of their tumors disappearing. The trial group included just 18 people, and there's still more to be learned about how the treatment worked. But some scientists say these kinds of results have never been seen in the history of cancer research. Dr. Hanna Sanoff of the University of North Carolina's Lineberger Comprehensive Cancer Center joined NPR's All Things Considered to outline how this drug works and what it could mean for the future of cancer research. Although she was not involved with the study, Dr. Sanoff has written about the results.
不吃高蛋白的话后续的手术化疗很难撑住吧
祝一切顺利，早日康复。
Big big bless!
我亲戚40岁得的，一直用colostomy,现在80多了还活着
Big Big Bless
祝福！完全恢复！
问问你的医生关于 AGEN1181, 这个药正在做clinical trial 关于某种colorectal cancer，目前临床效果不错. 祝福！
早治疗就好，我母亲四期，经历了30次放疗，十五次化疗，切除后搞了个人造造口，受了无数罪，最终还是走了。
Big big bless!!!
楼主再去做个详尽的 panel, 看看 PD1/PDL1 可不可以。如果dMMR 看看能不能进入临床试验https://ascopost.com/news/june-2022/unprecedented-100-of-first-14-untreated-patients-with-rectal-cancer-respond-to-pd-1-blocker-dostarlimab-gxly/
其他PD (L) 1 , 虽然目前还没有术前，但有不少一线二线的疗法和临床试验尤其在特定biomarker selected 人群，和医生商量下。
Big big bless!
https://www.nejm.org/doi/full/10.1056/NEJMoa2201445 The most recent trial with Dorstalimab is very impressive with dMMR mutation bearing rectal cancer patients (100% complete response, no need for surgery). I would highly recommend you reach out to the study team at Memorial Sloan Kettering Cancer Center: Dr. Cercek can be contacted at [email protected] or at Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065. Dr. Diaz can be contacted at [email protected] or at Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065.
中期不要犹豫，赶紧手术,这个肿瘤发展还是很快的，而且术后看病理切片如何，可能还需要继续化疗一段时间。保命重要！
Big Bless!!!
我之前没有做过肠镜，只是一般的体检。发现癌的这次是第一次肠镜检查。以前保险没报销的时候，没想过要去做，因为身体非常健康。完全想不到那里去。开始的时候，完全没症状，后来有便秘很严重的感觉。也就以为是便秘，痔疮这些了。
没怎么看懂，不过很感谢。
便秘是其中一个征兆。认识一个人就是每次10天一次便，后来确诊是肠癌，好几年了还活着。
可是，我反而看很多人说不要吃太多碳水化物，因为这是糖，癌症喜欢糖。我倒是不喜欢吃肉，可是，医生反而一直要求补蛋白质，特别是化疗， 需要蛋白质生血，生白细胞。
说得有道理
请问这个药是那个医院在做trail？ 知道主要医生的名字吗？
抱抱你，谢谢你分享这个信息给我。
谢谢你。 这个事，我和这个医生办公室联系过。他们跟我说了，我的不是他们药物针对的特定的那个类型。很遗憾。
谢谢。很可惜，这不是我的肿瘤类型。我问过了。
下面是部分内容，A tiny group of people with rectal cancer just experienced something of a scientific miracle: their cancer simply vanished after an experimental treatment. In a very small trial done by doctors at New York's Memorial Sloan Kettering Cancer Center, patients took a drug called dostarlimab for six months. The trial resulted in every single one of their tumors disappearing. The trial group included just 18 people, and there's still more to be learned about how the treatment worked. But some scientists say these kinds of results have never been seen in the history of cancer research. Dr. Hanna Sanoff of the University of North Carolina's Lineberger Comprehensive Cancer Center joined NPR's All Things Considered to outline how this drug works and what it could mean for the future of cancer research. Although she was not involved with the study, Dr. Sanoff has written about the results.
big big bless