随便找了一个文章, 用Plasmid做载体，在小动物实验里现在好像DNA都比较集中在注射区域，没有大面积的扩散. J&J的Ad26不知道会不会强力些. Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377020/ “it has been observed that regardless of the gene insert (expressing the vaccine immunogen or cytokine adjuvant) and regardless of the promoter used to drive expression of the gene insert in the plasmid backbone, the plasmid vaccines do not biodistribute widely and remain essentially in the site of injection, in the muscle and overlying subcutis.” 看完后结论是： 要远离重要的器官和神经, 所以应该打在屁股上
打过第一针强生的还要打强生吗？还是换mrna…… 有啥信息请大家踊跃分享…谢谢！
最主要的是,里面是不是换了Delta的S蛋白?
这种都能被实际应用? 超乎想象.
知道是哪家的有什么用？
正常人都知道正常情况下不会。
异常情况下，NOBODY KNOWS
J&J 有报告说有几个Guillain-Barre Syndrome, 这解释不是Viral DNA进了神经细胞, 被免疫系统攻击放倒了？
你就嫉妒吧 我们JJ党马上就要加入x-men队伍了
Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377020/
“it has been observed that regardless of the gene insert (expressing the vaccine immunogen or cytokine adjuvant) and regardless of the promoter used to drive expression of the gene insert in the plasmid backbone, the plasmid vaccines do not biodistribute widely and remain essentially in the site of injection, in the muscle and overlying subcutis.”
看完后结论是：
要远离重要的器官和神经, 所以应该打在屁股上
英国连自家的AZ都放弃了，而强生和AZ同类型。
novavax出来了吗