https://www.gov.uk/government/news/oxford-universityastrazeneca-vaccine-authorised-by-uk-medicines-regulator Press release Oxford University/AstraZeneca vaccine authorised by UK medicines regulator Government update on the Oxford University/AstraZeneca COVID-19 vaccine. Published 30 December 2020 From: Department of Health and Social Care The government has today accepted the recommendation from the Medicines and Healthcare products Regulatory Agency (MHRA) to authorise Oxford University/AstraZeneca’s COVID-19 vaccine for use. This follows rigorous clinical trials and a thorough analysis of the data by experts at the MHRA, which has concluded that the vaccine has met its strict standards of safety, quality and effectiveness.
全文 Press release Oxford University/AstraZeneca vaccine authorised by UK medicines regulator Government update on the Oxford University/AstraZeneca COVID-19 vaccine. Published 30 December 2020 From: Department of Health and Social Care The government has today accepted the recommendation from the Medicines and Healthcare products Regulatory Agency (MHRA) to authorise Oxford University/AstraZeneca’s COVID-19 vaccine for use. This follows rigorous clinical trials and a thorough analysis of the data by experts at the MHRA, which has concluded that the vaccine has met its strict standards of safety, quality and effectiveness. The Joint Committee on Vaccination and Immunisation (JCVI) will also publish its latest advice for the priority groups to receive this vaccine. The NHS has a clear vaccine delivery plan and decades of experience in delivering large scale vaccination programmes. It has already vaccinated hundreds of thousands of patients with the Pfizer/BioNTech vaccine and its roll out will continue. Now the NHS will begin putting their extensive preparations into action to roll out the Oxford University/AstraZeneca vaccine. Throughout this global pandemic we have always been guided by the latest scientific advice. Having studied evidence on both the Pfizer/BioNTech and Oxford University/AstraZeneca vaccines, the JCVI has advised the priority should be to give as many people in at-risk groups their first dose, rather than providing the required two doses in as short a time as possible. Everyone will still receive their second dose and this will be within 12 weeks of their first. The second dose completes the course and is important for longer term protection. From today the NHS across the UK will prioritise giving the first dose of the vaccine to those in the most high-risk groups. With 2 vaccines now approved, we will be able to vaccinate a greater number of people who are at highest risk, protecting them from the disease and reducing mortality and hospitalisation. The JCVI’s independent advice is that this approach will maximise the benefits of both vaccines. It will ensure that more at-risk people are able to get meaningful protection from a vaccine in the coming weeks and months, reducing deaths and starting to ease pressure on our NHS. To aid the success of the vaccination programme, it is vital everyone continues to play their part, abides by the restrictions in their area and remembers hands, face, space so we can suppress this virus and allow the NHS to do its work without being overwhelmed. Further details will be set out shortly.
https://www.bbc.co.uk/news/uk-55406939 Coronavirus: Impact of new variant on children investigated Scientists are urgently investigating hints the new variant of coronavirus spreads more easily in children. If proven, this could account for "a significant proportion" of the increase in transmission, they say. The claim comes from members of the government's New and Emerging Respiratory Virus Threats advisory group (Nervtag). On Monday, Boris Johnson said he wanted to open schools in January "if we possibly can". There are no suggestions the new form of the virus is a greater threat to children's health. What do we know? How worried should we be? The Oxford vaccine story Children almost universally shrug off the virus, but the variant could alter the role they, and schools, play in spreading the virus. Earlier strains of coronavirus found it harder to infect children than adults. One explanation is children have fewer of the doorways (the ACE2 receptor) the virus uses to enter our body's cells. A recent study of infections in schools in England found that levels of the virus in school-age children reflected levels in the local community, suggesting that closing schools would only have a temporary effect. Lightning speed Prof Wendy Barclay, from Nervtag and Imperial College London, said the mutations to the virus appeared to be making it easier to walk through the doorways that were there. She said this could be putting children on a "more level playing field" with adults as the virus was "less inhibited" in children. Prof Barclay said: "Therefore children are equally susceptible, perhaps, to this virus as adults, and therefore given their mixing patterns, you would expect to see more children being infected." Work to understand the new variant is taking place at lightning speed and there is still much uncertainty. It is now thought the new variant spreads 50% to 70% faster than other forms of the virus. Early analysis of how and where it is spreading have also given "hints that it has a higher propensity to infect children", according to Prof Neil Ferguson from the MRC Centre for Global Infectious Disease Analysis, who also sits on Nervtag. He stressed the link was still being investigated and was not yet proven. "If it were true, then this might explain a significant proportion, maybe even the majority, of the transmission increase seen," he added. But Prof Julian Hiscox, chair in infection and global health, from the University of Liverpool, told the BBC there wasn't any evidence "at the moment" that the new variant is able to infect children more efficiently. He said this would be looked at closely by scientists over Christmas. Scientists involved in COG-UK, the Covid-19 Genomics UK Consortium, which detected the rapid increase in the variant, said they were not aware of any increased incidence in children. 'Retain control' The data are continuing to be analysed, but it is thought the variant continued spreading even during the lockdown in November. The R number - the average number of people each infected person passes the virus onto - for this variant during the tight restrictions has been estimated at 1.2, which meant cases were increasing. At the same time the R number was 0.8 for the other forms of the virus during lockdown and they were in decline. Banner image reading 'more about coronavirus' SOCIAL DISTANCING: Can I give my friends a hug? FACE MASKS: When do I need to wear one? TESTING: How do I get a virus test? SYMPTOMS: What are they and how to guard against them? Banner Prof Ferguson said he expected the number of infections to fall as schools closed and people hunkered down for Christmas. He added: "The real question then is - how much are we able to relax measures in the new year, and still retain control?" Prime Minister Boris Johnson said: "We want, if we possibly can, to get schools back in a staggered way at the beginning of January, in the way that we have set out. "But obviously the common sensical thing to do is to follow the path of the epidemic and, as we showed last Saturday, to keep things under constant review."
大家自己感受下新变种的威力 The UK has recorded its highest daily increase in deaths from Covid-19 since April as 981 people have died within 28 days of developing coronavirus. This is the highest daily figure reported since April 24, when 1,010 deaths were reported - though there is likely to be a lag in reporting deaths over the Christmas period. The Department of Health also confirmed another 50,023 people have tested positive for Covid-19, bringing the total number of cases in the UK to 2,432,888. Separate figures published by the UK’s statistics agencies show that more than 88,000 deaths involving coronavirus have now occurred in the UK.
https://www.gov.uk/government/news/oxford-universityastrazeneca-vaccine-authorised-by-uk-medicines-regulator Press release Oxford University/AstraZeneca vaccine authorised by UK medicines regulator Government update on the Oxford University/AstraZeneca COVID-19 vaccine. Published 30 December 2020 From: Department of Health and Social Care The government has today accepted the recommendation from the Medicines and Healthcare products Regulatory Agency (MHRA) to authorise Oxford University/AstraZeneca’s COVID-19 vaccine for use. This follows rigorous clinical trials and a thorough analysis of the data by experts at the MHRA, which has concluded that the vaccine has met its strict standards of safety, quality and effectiveness.
大家自己感受下新变种的威力 The UK has recorded its highest daily increase in deaths from Covid-19 since April as 981 people have died within 28 days of developing coronavirus. This is the highest daily figure reported since April 24, when 1,010 deaths were reported - though there is likely to be a lag in reporting deaths over the Christmas period. The Department of Health also confirmed another 50,023 people have tested positive for Covid-19, bringing the total number of cases in the UK to 2,432,888. Separate figures published by the UK’s statistics agencies show that more than 88,000 deaths involving coronavirus have now occurred in the UK. 梅干茶泡饭 发表于 2020-12-30 12:54
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https://www.youtube.com/embed/HeYzFQA1PG0 今天报告死了981个 日增5W
我的感受就是 牛津疫苗和更多地区tougher lockdown一起宣布。给人一种，赶鸭子上架的感觉。撑不住了。。。 反正普通人轮上还早得很。看看大多数人打上什么样子吧。 英国肯特变种最大的变化就是在年轻人和小孩学校中传播迅速。虽然我原来也不相信什么“儿童传播能力弱”这种鬼话。。。
https://www.gov.uk/government/news/oxford-universityastrazeneca-vaccine-authorised-by-uk-medicines-regulator
Press release Oxford University/AstraZeneca vaccine authorised by UK medicines regulator Government update on the Oxford University/AstraZeneca COVID-19 vaccine. Published 30 December 2020 From: Department of Health and Social Care
The government has today accepted the recommendation from the Medicines and Healthcare products Regulatory Agency (MHRA) to authorise Oxford University/AstraZeneca’s COVID-19 vaccine for use. This follows rigorous clinical trials and a thorough analysis of the data by experts at the MHRA, which has concluded that the vaccine has met its strict standards of safety, quality and effectiveness.
Press release Oxford University/AstraZeneca vaccine authorised by UK medicines regulator Government update on the Oxford University/AstraZeneca COVID-19 vaccine. Published 30 December 2020 From: Department of Health and Social Care
The government has today accepted the recommendation from the Medicines and Healthcare products Regulatory Agency (MHRA) to authorise Oxford University/AstraZeneca’s COVID-19 vaccine for use. This follows rigorous clinical trials and a thorough analysis of the data by experts at the MHRA, which has concluded that the vaccine has met its strict standards of safety, quality and effectiveness.
The Joint Committee on Vaccination and Immunisation (JCVI) will also publish its latest advice for the priority groups to receive this vaccine.
The NHS has a clear vaccine delivery plan and decades of experience in delivering large scale vaccination programmes. It has already vaccinated hundreds of thousands of patients with the Pfizer/BioNTech vaccine and its roll out will continue. Now the NHS will begin putting their extensive preparations into action to roll out the Oxford University/AstraZeneca vaccine.
Throughout this global pandemic we have always been guided by the latest scientific advice. Having studied evidence on both the Pfizer/BioNTech and Oxford University/AstraZeneca vaccines, the JCVI has advised the priority should be to give as many people in at-risk groups their first dose, rather than providing the required two doses in as short a time as possible.
Everyone will still receive their second dose and this will be within 12 weeks of their first. The second dose completes the course and is important for longer term protection.
From today the NHS across the UK will prioritise giving the first dose of the vaccine to those in the most high-risk groups. With 2 vaccines now approved, we will be able to vaccinate a greater number of people who are at highest risk, protecting them from the disease and reducing mortality and hospitalisation.
The JCVI’s independent advice is that this approach will maximise the benefits of both vaccines. It will ensure that more at-risk people are able to get meaningful protection from a vaccine in the coming weeks and months, reducing deaths and starting to ease pressure on our NHS.
To aid the success of the vaccination programme, it is vital everyone continues to play their part, abides by the restrictions in their area and remembers hands, face, space so we can suppress this virus and allow the NHS to do its work without being overwhelmed.
Further details will be set out shortly.
https://www.news18.com/news/world/oxford-astrazeneca-covid-vaccine-can-be-up-to-80-effective-with-a-delay-between-doses-uk-official-3230228.html
讲真我更想打Pfizer的 不过两个都轮不上。。。就不做白日梦了。。。
外行问一句，两针之间那段时间有保护作用么？
不同的trial对illness的定义不一样。。。所以不好说。。。
说是有50%，聊胜于无吧，所以这三个月还是要注意
鬼话？ 这都是旧闻了 12月英国学校各种爆发 格林威治的学校和伦敦政府强烈要求关学校和中央政府闹起来的新闻估计你也没看 估计你也不知道目前英国中学提出条件必须每个孩子都测试才开学。。。
https://www.bbc.co.uk/news/uk-55406939 Coronavirus: Impact of new variant on children investigated Scientists are urgently investigating hints the new variant of coronavirus spreads more easily in children.
If proven, this could account for "a significant proportion" of the increase in transmission, they say.
The claim comes from members of the government's New and Emerging Respiratory Virus Threats advisory group (Nervtag).
On Monday, Boris Johnson said he wanted to open schools in January "if we possibly can".
There are no suggestions the new form of the virus is a greater threat to children's health.
What do we know? How worried should we be? The Oxford vaccine story Children almost universally shrug off the virus, but the variant could alter the role they, and schools, play in spreading the virus.
Earlier strains of coronavirus found it harder to infect children than adults.
One explanation is children have fewer of the doorways (the ACE2 receptor) the virus uses to enter our body's cells.
A recent study of infections in schools in England found that levels of the virus in school-age children reflected levels in the local community, suggesting that closing schools would only have a temporary effect.
Lightning speed Prof Wendy Barclay, from Nervtag and Imperial College London, said the mutations to the virus appeared to be making it easier to walk through the doorways that were there.
She said this could be putting children on a "more level playing field" with adults as the virus was "less inhibited" in children.
Prof Barclay said: "Therefore children are equally susceptible, perhaps, to this virus as adults, and therefore given their mixing patterns, you would expect to see more children being infected."
Work to understand the new variant is taking place at lightning speed and there is still much uncertainty.
It is now thought the new variant spreads 50% to 70% faster than other forms of the virus.
Early analysis of how and where it is spreading have also given "hints that it has a higher propensity to infect children", according to Prof Neil Ferguson from the MRC Centre for Global Infectious Disease Analysis, who also sits on Nervtag.
He stressed the link was still being investigated and was not yet proven.
"If it were true, then this might explain a significant proportion, maybe even the majority, of the transmission increase seen," he added.
But Prof Julian Hiscox, chair in infection and global health, from the University of Liverpool, told the BBC there wasn't any evidence "at the moment" that the new variant is able to infect children more efficiently.
He said this would be looked at closely by scientists over Christmas.
Scientists involved in COG-UK, the Covid-19 Genomics UK Consortium, which detected the rapid increase in the variant, said they were not aware of any increased incidence in children.
'Retain control' The data are continuing to be analysed, but it is thought the variant continued spreading even during the lockdown in November.
The R number - the average number of people each infected person passes the virus onto - for this variant during the tight restrictions has been estimated at 1.2, which meant cases were increasing.
At the same time the R number was 0.8 for the other forms of the virus during lockdown and they were in decline.
Banner image reading 'more about coronavirus' SOCIAL DISTANCING: Can I give my friends a hug? FACE MASKS: When do I need to wear one? TESTING: How do I get a virus test? SYMPTOMS: What are they and how to guard against them? Banner Prof Ferguson said he expected the number of infections to fall as schools closed and people hunkered down for Christmas.
He added: "The real question then is - how much are we able to relax measures in the new year, and still retain control?"
Prime Minister Boris Johnson said: "We want, if we possibly can, to get schools back in a staggered way at the beginning of January, in the way that we have set out.
"But obviously the common sensical thing to do is to follow the path of the epidemic and, as we showed last Saturday, to keep things under constant review."
难兄难弟。。。就等疫苗了。。。
真是复制了1918大流感的第二波疫情啊!
英国新变种非常厉害，取代了原来的流行种类，一定要小心! 全世界可能都逃不掉新变种扩散，大家都要在新年后注意防疫。
这是一个英国测序中心的数据(全基因组测序需要大约1周，所以数据还是滞后的)，橙色为新变种(共有4个突变)，蓝色为含有其中一个突变的其他所有变种:
S蛋白有1200多个氨基酸，而疫苗引起的免疫反应是多抗，针对S蛋白的多个位点。新变种突变了5个氨基酸，对于疫苗引起的免疫反应基本没影响，所以疫苗还是有作用的。 以后病毒再逐渐突变，可能最后会产生对疫苗不敏感的毒株，所以测序检测病毒变化是非常重要的工作。届时疫苗的生产和分发的基础设施都在，改变一下疫苗序列，应该不需要大规模三期临床测试就可以用了，所以应该会很快。
多谢科普。虽然没完全看懂，但是看到关键点。 1 疫苗还是有作用的 2 即使需要新的疫苗，也会很快 就感到安心一点。等疫苗接种完就好了。
谢谢，很有用的信息
还是不一样吧，这个变种没有让致死率大增吧，1918年第二波很多健康年轻人丧命，英国的这个变种好像不是这样吧
延长是三个月，太长了，这三个月内会有多少人感染呀
谢谢科普。。。。。。。