Covid-19 vaccine: Allergy warning over new jab People with a history of significant allergic reactions should not have the new Covid jab, regulators say. It came after two NHS workers had allergic reactions on Tuesday. The Medicines and Healthcare products Regulatory Agency (MHRA) said the advice applies to anyone who has had significant reactions to medicines, food or vaccines. The two people had a reaction shortly after having the Pfizer/BioNTech jab, had treatment and are both fine now. They are understood to have had an anaphylactoid reaction - much milder than anaphylaxis - which tends to involve a skin rash, breathlessness and sometimes a drop in blood pressure. Both NHS workers have a history of serious allergies and carry adrenalin pens around with them. Professor Stephen Powis, medical director for the NHS in England, said both individuals are recovering well. "As is common with new vaccines, the MHRA have advised on a precautionary basis that people with a significant history of allergic reactions do not receive this vaccination after two people with a history of significant allergic reactions responded adversely," he said. Dr June Raine, head of the MHRA, said it was only right to take this step now that "we''''ve had this experience". Reactions like this are uncommon, but do happen with other vaccines, including the annual flu jab. Similar reactions were not seen in the clinical trials for this drug in which more than 20,000 people were vaccinated, although people with a history of allergic reactions would not have been recruited. Several thousand people were vaccinated on Tuesday in hospital clinics on the first day of the UK rollout of the new Covid jab.
Shakespeare gets Covid vaccine: All''''s well that ends wellhttps://www.bbc.co.uk/news/uk-55233021 The True Winter''''s Tale Margaret Keenan has made history by becoming the first person in the world to get a Covid-19 vaccine outside of a clinical trial, but if there''''s one name you''''ll associate with this day, it may not be hers. Enter, pursued by puns, William Shakespeare. Not the writer, poet and playwright, but his 81-year-old namesake. This Mr Shakespeare was the second person to be given a jab - and, guess what, he also comes from Warwickshire. "Much ado about nothing?" It doesn''''t matter - "all''''s well that ends well". "Is this a needle which I see before me?" the present-day Shakespeare could have asked, but his reaction was a little bit less, well, dramatic: he said he was "pleased" to be given the jab, and staff at University Hospital in Coventry had been "wonderful". So, if Ms Keenan was patient 1A, was Mr Shakespeare "Patient 2B or not 2B"? Theirs were the first of 800,000 doses of the Pfizer/BioNTech vaccine that will be dispensed in the coming weeks in the UK. 英国于周二起开始接种新冠疫苗，并为高危群体优先接种。在英国首名接种新冠疫苗的是一名90岁婆婆，紧接第二名的是在同一医院打针，与英国著名戏剧家及诗人同名同姓的，来自同一个郡的81岁莎士比亚William Shakespeare，因而被网友戏称正上演“驯流感记” The Taming of the Flu 。
接触的东西太单一,比如父母听说花生过敏的人多就不给孩子吃花生,反而造成了花生过敏.现在都是推尽早接触敏感物质. Let them eat dirt, but try to protect them from harmful germs, and give them the capacity to fight diseases.
接触的东西太单一,比如父母听说花生过敏的人多就不给孩子吃花生,反而造成了花生过敏.现在都是推尽早接触敏感物质. Let them eat dirt, but try to protect them from harmful germs, and give them the capacity to fight diseases. doorsopen 发表于 2020-12-09 11:28
Let them eat dirt, but try to protect them from harmful germs, and give them the capacity to fight diseases. 具体说来就是该打疫苗还是要打.带孩子去医院或者诊所的时候不要让孩子乱摸乱舔.在家里可以自由些,能带孩子去户外接触土地花草动物会有帮助.教给孩子好的卫生习惯,该洗手要洗手.同时吃好睡好心情好,就算生病也好得快.
回复 78楼doorsopen的帖子 Here are the key points you should consider until we have more evidence: if you are pregnant you should not be vaccinated – you can be vaccinated after your pregnancy is over if you think you may be pregnant you should delay vaccination until you are sure you are not if you are planning to get pregnant in the next 3 months, you should delay your vaccination if you know you are not pregnant you can start the two-dose course now and you should avoid getting pregnant until at least 2 months after the second dose if you have had the first dose and then become pregnant you should delay the second dose until after the pregnancy is over If you are breastfeeding you should wait until you have finished breastfeeding and then have the vaccine. If you were breastfeeding when you had the first dose you are advised not to have the second dose until you have finished breastfeeding. This advice is precautionary until additional evidence is available to support the use of this vaccine in pregnancy and breastfeeding. It may then be possible to have the Pfizer-BioNTech vaccine. Until that advice is changed you may be able to have one of the other COVID-19 vaccines that are expected. https://www.gov.uk/government/publications/covid-19-vaccination-women-of-childbearing-age-currently-pregnant-planning-a-pregnancy-or-breastfeeding/covid-19-vaccination-a-guide-for-women-of-childbearing-age-pregnant-planning-a-pregnancy-or-breastfeeding
回复 1楼梅干茶泡饭的帖子 "Both NHS workers have a history of serious allergies and carry adrenalin pens around with them." 这样严重过敏而且随身带东西治疗过敏的人恐怕连吃的东西都要单独做，不能吃的东西一大堆。 放成break news有点标题党的感觉。
回复 1楼梅干茶泡饭的帖子 "Both NHS workers have a history of serious allergies and carry adrenalin pens around with them." 这样严重过敏而且随身带东西治疗过敏的人恐怕连吃的东西都要单独做，不能吃的东西一大堆。 放成break news有点标题党的感觉。 yoyo2007 发表于 2020-12-09 20:43
People with a history of significant allergic reactions should not have the new Covid jab, regulators say.
It came after two NHS workers had allergic reactions on Tuesday.
The Medicines and Healthcare products Regulatory Agency (MHRA) said the advice applies to anyone who has had significant reactions to medicines, food or vaccines.
The two people had a reaction shortly after having the Pfizer/BioNTech jab, had treatment and are both fine now.
They are understood to have had an anaphylactoid reaction - much milder than anaphylaxis - which tends to involve a skin rash, breathlessness and sometimes a drop in blood pressure.
Both NHS workers have a history of serious allergies and carry adrenalin pens around with them.
Professor Stephen Powis, medical director for the NHS in England, said both individuals are recovering well.
"As is common with new vaccines, the MHRA have advised on a precautionary basis that people with a significant history of allergic reactions do not receive this vaccination after two people with a history of significant allergic reactions responded adversely," he said.
Dr June Raine, head of the MHRA, said it was only right to take this step now that "we''''ve had this experience".
Reactions like this are uncommon, but do happen with other vaccines, including the annual flu jab.
Similar reactions were not seen in the clinical trials for this drug in which more than 20,000 people were vaccinated, although people with a history of allergic reactions would not have been recruited.
Several thousand people were vaccinated on Tuesday in hospital clinics on the first day of the UK rollout of the new Covid jab.
Shakespeare gets Covid vaccine: All''''s well that ends well https://www.bbc.co.uk/news/uk-55233021
The True Winter''''s Tale
Margaret Keenan has made history by becoming the first person in the world to get a Covid-19 vaccine outside of a clinical trial, but if there''''s one name you''''ll associate with this day, it may not be hers.
Enter, pursued by puns, William Shakespeare.
Not the writer, poet and playwright, but his 81-year-old namesake. This Mr Shakespeare was the second person to be given a jab - and, guess what, he also comes from Warwickshire.
"Much ado about nothing?" It doesn''''t matter - "all''''s well that ends well".
"Is this a needle which I see before me?" the present-day Shakespeare could have asked, but his reaction was a little bit less, well, dramatic: he said he was "pleased" to be given the jab, and staff at University Hospital in Coventry had been "wonderful".
So, if Ms Keenan was patient 1A, was Mr Shakespeare "Patient 2B or not 2B"?
Theirs were the first of 800,000 doses of the Pfizer/BioNTech vaccine that will be dispensed in the coming weeks in the UK.
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https://www.youtube.com/embed/1rCFyroIbp4
好奇天天盯着国内做啥。国药疫苗阿联酋批准都还没排上热搜呢。
其实我很奇怪为啥美国小孩过敏的这么多
新闻里面写的是有严重过敏史的 不知道花生过敏算不算
花生过敏肯定算的，我也觉得美国孩子过敏的比国内的多。
为什么呢？环境太干净了吗？我到了美国之后也是年年过敏，年年加重，现在每周吃抗敏药。以前在中国只有小学的时候过敏过，
打之前肯定填表了的啊。你没打过疫苗吧？
这也是我生理教授当年在课堂上教的。婴儿成长过程中需要接触各种各样的物质，学会哪些是正常无害的那些是需要有免疫反应的。太多卫生规则和，这个purified,那个hypoallergenic, 反而导致过敏。
达尔文故乡。。。胆子是大的 不过这几个都是医务人员 估计也是做好准备了吧
目前疫苗roll out都是在医院进行
不干不净吃了没病的意思么
FDA通过疫苗我是会去注射的，但对于这个疫苗我还是有点顾虑，的确是测试人数和时间都不够常规的新药需要的数据。 我是不同意疫苗完全安全无害观点， 毕竟任何新药即使临床应用也有追踪观察期， 更何况这是个完全没有用过的mRNA疫苗。疫苗可不只是給一个很小的百分比的病人治病的药， 而是需要普及到每个人的预防性药物，谨慎些也是很应该的，所以我很莫名其妙版上有些人一口咬定疫苗安全无害，任何反对的都是居心叵测，至于吗？ 我想这些道理， 执政者们不会不懂， 只是各种风险导致无法按常规新药的测试批准途径进行， 时间太长等不起， ，安抚群众稳定社会， 尽快恢复正常工作挽救经济， 过多的人患病会导致医疗系统崩溃， 以及越来越多的死亡人数， 所以只能是在风险和利益之间权衡，且先渡过眼下的危机。
别瞎扯了。过敏多是因为太赶紧了。
那日本和瑞士的孩子比美国过敏的比例更高吗？
我倒不觉得瑞士人很干净啊。。。 他们蛮原生态的。。。
我倒是觉得会不会吃工业加工消毒过的食品太多有影响？
其实我比较担心第一批疫苗在医护工作者里进行。现在是最需要他们得时候，他们可不能出错。反过来说，说明决策者对疫苗有足够的信心才让医护工作者先打上。
确实现在这个形势下没有时间去等。不知道人类过几十年会不会经历这次病毒和疫苗的后遗症。
除了本土印第安人，全美国人都过敏？
4、50年前在美国过敏也不像现在这样广泛
这个怀疑有一定道理，美国很多食品加工过度。以前一个朋友说他家孩子吃全花生没事，吃花生酱就不行
日本人对花粉过敏 原因是政府种的的杉树，但是树太多了也不好砍 日本习惯了戴口罩
既然在测试阶段，排除了有过敏历史的志愿者，说明他们不在接种之列，为何现在让这样的人打？也许他们这次是志愿测试疫苗的界限？
你好像也是一样盯着。既然如此，中国自己有没有正式批准开打疫苗？
新冠疫苗enroll的人数是够的，HPV和shingle疫苗都只enroll了一万多人，新冠疫苗pfizer和moderna都是3-4万人。
有顾虑很正常，但衡量疫苗的可能害处是要和被病毒感染可能的后果比较的，病毒也是全新的，感染后果也不可预测。就看你有多大可能被感染，值不值得承担这个风险。FDA如果批了，每个人可以根据自己的情况选择打或者不打，我觉得挺好的。
试试CoQ10，我今年吃了，竟然没过敏，以前年年过敏，必须吃药的。
讲真我觉得英国就是在做大规模后三期实验呢。。。
也有可能是你今年带口罩了，所以不过敏。我们全家因为带口罩多了，今年过敏症状轻很多
是 你们真惨
过敏季的时候还没开始戴口罩。。。
我觉得美国人就是狡猾，成心拖到英国先上。
然而HPV和shingle的疫苗并不是所有人都打。另外我顾虑的是mRNA疫苗的长期安全性， 这个跟enroll多少人有关系，跟时间更有关系，现在的天数还不够得出安全的结论。
能讲讲理论上可能的风险是啥吗？进入dna?
mrna是不会进入dna的哈， mrna应该会被ribosome 读成protein，生成抗体
那有啥可能的风险？rna疫苗？只是理论上
不是。我不是搞免疫的， 不能很准确的解释，但mRNA疫苗的顾虑， 应该是会不会产生意外的免疫反应，以及，由于mRNA的快速分解特性， 那么即时能产生新冠免疫， 这个效果能保持多久。
mRNA几分钟就降解了，主要风险就是对mRNA和脂质载体过敏，再就是对spike protein本身的免疫反应。后者在大流行期间的风险可以忽略，因为感染了病毒以后病毒会生成更多的spike protein
接触的东西太单一,比如父母听说花生过敏的人多就不给孩子吃花生,反而造成了花生过敏.现在都是推尽早接触敏感物质. Let them eat dirt, but try to protect them from harmful germs, and give them the capacity to fight diseases.
抓住层主问一下，Moderna的疫苗应该是修饰过的RNA, 所以稳定性比较好。有对修饰过的核酸过敏的可能性吗?
Let them eat dirt, but try to protect them from harmful germs, and give them the capacity to fight diseases.
具体说来就是该打疫苗还是要打.带孩子去医院或者诊所的时候不要让孩子乱摸乱舔.在家里可以自由些,能带孩子去户外接触土地花草动物会有帮助.教给孩子好的卫生习惯,该洗手要洗手.同时吃好睡好心情好,就算生病也好得快.
现在还有一个未知，就是打了疫苗能不能防止传播病毒，如果不能，设想那些打了的人觉得自己有了免疫力开始当初浪，他们是不会病，但是会把病毒传给没打疫苗的人，他们还是会病，不打不是更危险？
讲真八十岁以上的其实顾虑最少了 管它什么long term effects....
不惨不惨 达尔文的故乡 牛痘疫苗的故乡 大家还是很有为科学献身。。精神的。。。。
甚至给昨天起名叫Vday 谐VE day的典故
噢 还有为了激起民众热情 特地宣传 “法国佬讽刺我们打疫苗太着急”。。。
Anaphylactoid reaction 谁说不严重？症状跟anaphylaxis 是一样的，机理有点不一样，前者不是因为IgE导致的，所以第一次exposure就出现了，严重的得不到及时治疗会死人的
最后一句太有画面感了。
一直都忽略了英国人那么有献身精神 哈
不过确实老年人的side effect也算了 小孩子如果这样会很吓人
是的，mRNA疫苗以前是给癌症病人做的，癌症病人不会考虑长期后果的
加州说会分批次给医护打，避免反应造成太多人不能上班，之前的测试显示有人会有两天比较明显的反应
很期待看看女王夫妇会不会打 按理说他们是第一波eligible的超高龄人群
女王年轻的时候 也有过群众不信任疫苗的事情 然后女王就给查尔斯和安妮打了 虽然女王没上过大学 但还是挺相信科学的
这个mm好懂，抓住问问，就是mrna疫苗不会有太大风险是吗？现在谣言不少。
有疑虑可以理解 你愿意注射就好。不像有些自私的人人让别人都去打了自己去享受群免的好处。
长期的follow up肯定要做，但是理论上讲没有什么机制让mRNA能引发长期副作用，比如说十年之后的癌症什么的。真要说长期副作用的话其实灭活疫苗里面的氢氧化铝好像更有问题。。。
是啊，还有最近炒得比较火的fertility影响。50岁以上就根本不用考虑这个了。活命才是最重要的。
楼主是明贬实褒啊
也可能你今年一直带着口罩？
几千人就出现了2个anaphylactoid reaction 还少啊？你们是不是对anaphylactoid reaction有误解？比发烧啥的严重多了。
Anaphylactoid reaction 和anaphylaxis 的区别是前者直接导致histamine和其他活性物质释放，后者要通过IgE再释放(至少2次exposure), 都能导致rash, 呼吸困难，脸面喉咙肿，血压下降
过敏反应的范围可以很广
这次没法自私，主要是疫苗不一定对传播效率的有效性还没有定论。辉瑞是应该有内部data 的。
所有的药物疫苗面临一样的安全风险问题。
很多人精神有问题。 比如反转基因食品的。。。
意外的免疫反应？您是说灭火疫苗，打进去一堆东西？
Being warned against the immunisation by experts, the three groups told not to vaccinate themselves against coronavirus are pregnant women, children under 16 and those with allergies.
https://www.lbc.co.uk/news/who-cant-have-covid-19-vaccine/
Here are the key points you should consider until we have more evidence: if you are pregnant you should not be vaccinated – you can be vaccinated after your pregnancy is over if you think you may be pregnant you should delay vaccination until you are sure you are not if you are planning to get pregnant in the next 3 months, you should delay your vaccination if you know you are not pregnant you can start the two-dose course now and you should avoid getting pregnant until at least 2 months after the second dose if you have had the first dose and then become pregnant you should delay the second dose until after the pregnancy is over
If you are breastfeeding you should wait until you have finished breastfeeding and then have the vaccine. If you were breastfeeding when you had the first dose you are advised not to have the second dose until you have finished breastfeeding.
This advice is precautionary until additional evidence is available to support the use of this vaccine in pregnancy and breastfeeding. It may then be possible to have the Pfizer-BioNTech vaccine. Until that advice is changed you may be able to have one of the other COVID-19 vaccines that are expected.
https://www.gov.uk/government/publications/covid-19-vaccination-women-of-childbearing-age-currently-pregnant-planning-a-pregnancy-or-breastfeeding/covid-19-vaccination-a-guide-for-women-of-childbearing-age-pregnant-planning-a-pregnancy-or-breastfeeding
基因缺陷。
anaphylactoid reaction是常见的过敏反应，打其他疫苗像是flu shot也一样，要你等15分钟才能离开就是为了确定没有trigger anaphylactoid reaction
真悲哀，出去了还这么关注国内的落后面，酱缸呆久了已经养成酱性了吗
"Both NHS workers have a history of serious allergies and carry adrenalin pens around with them." 这样严重过敏而且随身带东西治疗过敏的人恐怕连吃的东西都要单独做，不能吃的东西一大堆。 放成break news有点标题党的感觉。
mrna疫苗從來沒有批准過在人類使用，怎麼有以前的說法？
不会全民接种的。不是每个政府都有北朝鲜那么大的权利的。
CoQ10这种东西就是骗钱的。很多人在研究如何让这东西进入细胞，好多CoQ10机能障碍的病人吃这个都没有任何可以证实的效果，普通人就更没用了。
明明就是trial之前也预见过，其他常规疫苗像是流感疫苗特别是灭活疫苗也都会有的过敏反应，搞得好像就是这个mRNA疫苗特有的一样，非常居心叵测。
过敏和过敏不一样
flu shot通常是鸡蛋过敏 因为疫苗是通过鸡蛋造出来的
这个和鸡蛋没有关系的 是mRNA疫苗本身的机理会对auto-immune产生影响
不是只有一半人打疫苗吗？
HPV, shingles也是，一万人里一半疫苗一半placebo.
“mRNA疫苗本身的机理会对auto-immune产生影响” 有科学依据吗？还是自己拍脑袋想出来的？
flu shot 里trigger anaphylactic reaction的是蛋白质，只是它来源鸡蛋，mRNA疫苗里没有鸡蛋不等于没有蛋白质，它会产生spike protein，这种protein在covid上也存在，有蛋白质自然和flu shot一样有机会引发过敏反应，灭活疫苗里常带protein，所以常规操作是打完需要15分钟monitor potential anaphylactic reaction。而且就spike protein来说，如果过敏那感染了covid同样会激发过敏反应
那是问对疫苗的成分有没有过敏，不是食物会药物过敏。 看来吗mRNA对免疫功能比较刺激， overly reactive immune system的人受不了
这些年美国人和吃了猪饲料似的，长成500磅的也很多。以前电视里美国人好像都没那么胖的