The FDA is responsible for ensuring that U.S. medicines are manufactured in safe, sanitary conditions. But regulators have struggled for years to inspect the supply chain as pharmaceutical production has spread globally. For decades the FDA focused its manufacturing inspections on U.S. factories. But over time, most companies have moved their manufacturing overseas to take advantage of cheaper labor and materials. Today, roughly 80% of the ingredients used in U.S. drugs are manufactured abroad, primarily in India and China, according to the Government Accountability Office. Ranitidine, as the drug is known in generic form, is an antacid and antihistamine used to treat and prevent a range of gastrointestinal disorders. The chemical NDMA, or N-Nitrosodimethylamine, is a likely human carcinogen found in cooked or cured meats such as bacon, and is a common industrial byproduct. The discovery further underscores the challenge pharmaceutical-industry regulators face in overseeing a vast global supply chain of drugs, drug ingredients and factory processes. Dozens of versions of the hypertension treatment valsartan have been recalled since last year out of concern they could be contaminated with NDMA. Many of those drugs were made in China or India, raising questions about the quality of generic manufacturing in far-flung factories around the globe. The review of ranitidine comes after Valisure, a New Haven, Connecticut-based online pharmacy that tests all the medications it dispenses, alerted the U.S. Food and Drug Administration that it had detected high levels of NDMA in both generic and brand versions of Zantac sold at major pharmacies run by companies including Walgreens Boots Alliance Inc., CVS Health Corp. and Walmart Inc.
洛赛克prilosec可以替代。问题是致癌物是混入的污染物怎么知道别的药有没有。
☆ 发自 iPhone 华人一网 1.14.05
新闻说这个药是墨西哥生产的，药品成分来自西班牙，关中国什么事？
☆ 发自 iPhone 华人一网 1.14.05
最好去退了，CNBC上说的就是Zantac。
https://www.google.com/amp/s/www.wsj.com/amp/articles/fda-finds-probable-carcinogen-in-some-versions-of-zantac-11568389534
☆ 发自 iPhone 华人一网 1.14.05
☆ 发自 iPhone 华人一网 1.14.05
☆ 发自 iPhone 华人一网 1.14.05
刚看文学城新闻，说是致癌物超标。我最近胃不舒服，正在吃，还好是刚开始吃，准备扔掉了。我知道pepcid跟zantac差不多，还有其他药可以替代zantac的吗？
Brand name也一样有。因为制药厂的各种化学成分80%来自中国和印度。
去年降压药被发现有致癌污染也是同类致癌物。
The FDA is responsible for ensuring that U.S. medicines are manufactured in safe, sanitary conditions. But regulators have struggled for years to inspect the supply chain as pharmaceutical production has spread globally. For decades the FDA focused its manufacturing inspections on U.S. factories. But over time, most companies have moved their manufacturing overseas to take advantage of cheaper labor and materials. Today, roughly 80% of the ingredients used in U.S. drugs are manufactured abroad, primarily in India and China, according to the Government Accountability Office.
Ranitidine, as the drug is known in generic form, is an antacid and antihistamine used to treat and prevent a range of gastrointestinal disorders. The chemical NDMA, or N-Nitrosodimethylamine, is a likely human carcinogen found in cooked or cured meats such as bacon, and is a common industrial byproduct. The discovery further underscores the challenge pharmaceutical-industry regulators face in overseeing a vast global supply chain of drugs, drug ingredients and factory processes. Dozens of versions of the hypertension treatment valsartan have been recalled since last year out of concern they could be contaminated with NDMA. Many of those drugs were made in China or India, raising questions about the quality of generic manufacturing in far-flung factories around the globe. The review of ranitidine comes after Valisure, a New Haven, Connecticut-based online pharmacy that tests all the medications it dispenses, alerted the U.S. Food and Drug Administration that it had detected high levels of NDMA in both generic and brand versions of Zantac sold at major pharmacies run by companies including Walgreens Boots Alliance Inc., CVS Health Corp. and Walmart Inc.
FDA可没说brand name没事，还在调查中，FDA也没有说必须停药，不过患者不放心的话可以咨询医生或者药剂师换药。
https://www.fda.gov/news-events/press-announcements/statement-alerting-patients-and-health-care-professionals-ndma-found-samples-ranitidine
NDMA 不是药物成分，但是可能在药物分解的过程中产生，并且内部消息说有实验证明口服正常药物后，在尿液中检测到NDMA，而且NDMA通过尿液排出体外之后，继续污染public water system。当然每个州都有monitoring public water，NDMA是重要检测物质。
更重要的是zantac不像之前曝光的心血管类药物，是完全有安全替代药物的，FDA这次首先是不想造成恐慌，并且很有可能sweeping it under the rug，捅开了不知道要牵扯多少lawsuit
有儿医给吐奶小宝宝开zantac，我觉得至少这个操作应该是尽量避免。