回头在看看美国大名鼎鼎的美国病毒学教授Ralph Baric主持的研究，石正丽作者之一发表在2015年11月nature medicine上的实验室制造萨斯样病毒的文章更值得玩味。https://www.nature.com/articles/nm.3985
这是作者贡献
AUTHoR conTRIBUTIonS V.D.M. designed, coordinated and performed experiments, completed analysis and wrote the manuscript. B.L.Y. designed the infectious clone and recovered chimeric viruses; S.A. completed neutralization assays; L.E.G. helped perform mouse experiments; T.S. and J.A.P. completed mouse experiments and plaque assays;
X.-Y.G. performed pseudotyping experiments; K.D. generated structural figures and predictions; E.F.D. generated phylogenetic analysis; R.L.G. completed RNA analysis; S.H.R. provided primary HAE cultures; A.L. and W.A.M. provided critical monoclonal antibody reagents; and Z.-L.S. provided SHC014 spike sequences and plasmids. R.S.B. designed experiments and wrote manuscript.
更可笑的是作者在2016,2020两次修改了论文：））
这篇文章出之一位曾经在德里克堡（Fort Detrick）实验室工作过的印度人，关于新冠病毒的源头比较令人信服，随便看看吧。
【译文】
萨曼莎·希尔（Samantha Hill）
抱歉，我们在新型冠状病毒爆发中扮演了邪恶角色
我匿名发帖。我曾是个美国人，但更多是印度人。我曾在曼尼托巴大学读书，并在德里克堡（Fort Detrick）实验室做过一些杂活。我上司和我几乎完全了解新冠病毒的一切，他也是因此而被杀害的。现在我回到了印度，振作精神，决定说出真相，希望大家了解到真相时我还活着。
我工作的地方相当神秘，是许多军方生物武器和化学武器的研发基地，有最高机密性。像我这样的小角色只能胜任服务客户公司的工作，无法接触到任一实验的全部信息。
我的头号客户是吉利德科学（Gilead Sciences）公司。他们曾在中东传播中东呼吸综合征（MERS），以便避开联邦限制，测试一种新药的药效。他们已经用瑞德西韦进行过各种人体安全性测试了，这是个公开的秘密，但我主要要说的并不是这个。
我的上司是弗兰克·普拉默（Frank Plummer）教授，他曾是拉斐尔·巴里克（Ralph S. Baric）教授最好的朋友。他俩在生物科学领域都取得了巨大成就，这必定是湿婆神的保佑，我们凡夫俗子无法企及。普拉默教授相对更保守，而巴里克教授则是一位科学狂人，经常做一些高风险实验。我到现在才理解，他这么做很可能不是出于自己的意愿，而是被吉利德科学公司要求的。
在我们发现吉利德科学公司研发的编号为GS-5734的药物抗击埃博拉病毒非常有效后，对其进行了多次实验。该化合物很可能是一种广谱抗病毒药物，其作用机理非常特殊，与众不同，因此我们针对一系列单链RNA病毒进行了实验，包括拉沙热病毒（Lassa fever virus）、尼帕病毒（Nipah virus）、亨德拉病毒（Hendra virus）及冠状病毒等。我们在冠状病毒实验中遇到了一些特殊情况，尚不清楚GS-5734能否有效抗击MERS和SARS。为了进一步进行研究，吉利德科学公司的阿德里安·雷（Adrian S. Ray）和理查德·马克曼（Richard L. Mackman）分别委托北卡罗来纳大学疾控中心的美国陆军医学传染病研究所（United States Army Medical Research Institute of Infectious Diseases）进行了不同领域的研究，以下这些在线论文也正是由他们发表的。这些项目的负责人包括希娜·巴维利（Sina Bavari）（小分子GS-5734对恒河猴埃博拉病毒的治疗功效，Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys，Warren et al., 2016）、克里斯蒂娜·斯皮罗普罗（Christina F. Spiropoulou）（GS-5734及其母体核苷类似物对丝状病毒、肺病毒和副黏液病毒的抑制，GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses，Lo, et al. 2017）、拉斐尔·巴里克等（广谱抗病毒GS-5734对人畜共患的流行冠状病毒的抑制，Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses，Sheahan et al., 2017）。到目前为止，我们实验中使用的所有SARS样本均来自巴里克教授组，因为他是制造SARS的专家，发表过《重症急性呼吸综合征冠状病毒全长感染cDNA的反向遗传学》的论文（Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus，Yount, et al., 2003），这意味着他从2003年起就可以复制SARS病毒，不受任何限制。他还为中国科学院提供了研究经费，让石正丽扮演了天真的白雪公主——帮助他确定了中国南方变异SARS的基因变异片段。
实际上，自从石正丽在中国发现的SHC014基因片段被巴里克教授采用，并于2015年在德里克堡实验室合成为一种新型病毒——即如今的新型冠状病毒之后，石正丽就已经完成了巴里克教授交给她的任务。
这是一次伟大的实验，在病毒学和生物学上取得了巨大的进步，因为这种RNA的合成是前所未有的。普拉默教授一直反对这一实验，认为它违背了科学道德。但巴里克教授和吉利德科学公司坚持认为这种合成病毒可以在对比实验中作为原始SARS病毒的参考，是GS-5734药物实验必不可少的原料。
据我所知，人工繁殖新型SARS病毒应该是由国防部委托的一项开发生物武器的研发项目。但吉利德科学公司也有自己的秘密计划：一旦病毒泄漏并传播，他们将以极高昂的价格在全球出售GS-5734。
需要说明的是，新冠病毒在全球的肆虐并不是吉利德科学公司或国防部有意采取的行动，而是实验泄漏导致的。2019年5月，我们实验中出现了一次泄漏，但直到疾控中心于2019年7月发现马里兰州的实验室附近有村民受到感染，我们才意识到这次泄漏。我们后来发现实验室的废水处理系统存在严重问题，但为时已晚了。
互联网上流传的推测性事实并不完全准确：当时在南美肆虐的流感并非完全是SARS-II（即新冠病毒），而是两种病毒同时传播造成的。由于疾控中心的干涉，位于各个州的前哨实验室没有进行冠状病毒测试。
由于巴里克教授的建议，我们的实验室、军方和吉利德科学公司都不会承认病毒的来源，而是默认将中国云南省的蝙蝠作为病毒来源。由于中国科学家的实验和论文已经证明了自然界中的基因变异及SARS-I原型起源于中国，这么做是可行的。
新冠病毒的传播中存在一些争议话题。为了确保该病毒不会造成无法收拾的损害，疾控中心在中情局的协助下启动了EVENT201演习。尽管演习结果不尽人意，巴里克教授还是认为，由于ACE2基因在不同种族中的分布不同，SARS-II不会对美国白种人造成巨大伤害。这就是中央情报局最终决定不对病毒传播进行预警的原因。
巴里克教授、吉利德科学公司、黑石公司（BlackRock，吉利德科学公司的投资子公司）和疾控中心是整个事件的决策者。会议的所有成员都是共和党人，他们向美国创新办公室和杰拉德·库什纳（Jared Kushner）汇报。
2019年12月是转折点，当时一名水手受到SARS-II感染后继续工作，碰巧将病毒封装在了海鲜包装中，后者随后经由非法市场运到了中国武汉的海鲜市场。出人意料的是，中國的防疫部門發現了這種病毒，這很可能要歸功於他們的SARS預防經驗。不然的話，這種病毒性肺炎可能會被當做細菌性肺炎，並被稱做一種新型流感，不會引起足夠的重視。
中國政府發現SARS-II後，我的上司普拉默教授打算與中國科研機構分享採用GS-5734對抗SARS-II的經驗，但他在從肯尼亞飛往中國時被暗殺了。得知這一消息後，我不得不回到印度躲藏起來。
據我所知，一些知道真相的同事在過去的幾個月中被殺害了，另一些則消失了。其他所有屈服於巴里克教授的從業者未經他的許可都不敢表達他們的懷疑。一旦提出質疑，他們的職業生涯就將結束，不會再有出版商接受他們的論文。
我不知道我還能在世上活多久，我內心深處感到內疚。我不能讓這麼多人連真相也不清楚就白白死去，所以我在此將其公之於眾，願濕婆神保佑大家。他們當然會否認所有這一切，甚至會否認我的身份乃至我的存在。他們會盡全力殺害我，所以我就在這裡說再見了。大家再見！我很抱歉！
Samantha Hill
Sorry, we played an evil part in the outbreak of COVID-19
I am anonymous, I used to be an American, but I am more of an Indian. I learnt in the University of Manitoba and did some trivial work in the Fort Detrick Laboratory after graduation. My supervisor and I know almost
everything about COVID-19, and that’s why he was killed. Now I came back to India. I gather myself up and decide to tell the truth, hoping I will still be alive when all of you learn the truth.
The place I worked was quite mysterious and it is where many military biological weapons and chemical weapons are researched and developed, which is the highest level of confidentiality. Inferiors as me could only be qualified to serve the client company, but I still didn't have the clearance for all the information about any single experiment.
Gilead Sciences was my No.1 enterprise which I served most. They ever spread MERS in the Middle East so as to test the effects of a new medicine but dodge the federal restrictions. It has been an open secret that they had done experiments with GS-5734 on human being with any safety test, however, this is not what I mainly intend to say.
My supervisor was Professor Frank Plummer who used to be the best friend of Professor Ralph S. Baric. Both of them had made great and significant achievements in bioscience which must be the power entitled by Lord Shiva, but unattainable for us. Professor Plummer was more conservative while Professor Baric was a science-maniac who usually did some highly-risky experiments. I did not understand until now that he probably did not do it out of his own will but was required to do so by Gilead Sciences Inc..
Multiple experiments had been carried out after we learnt that the medicine with code of GS-5734, researched and developed by Gilead Sciences Inc., was quite effective against Ebola. This compound was probably a broadspectrum antiviral medicine and how it worked was quite special and different, thus we did experiments on a number of a single-stranded RNA viruses, including Lassa fever virus, Nipah virus, Hendra virus, coronavirus. Something special happened when we did experiments on coronavirus. It was not quite clear whether GS-5734 could effectively fight against MERS and SARS. In order to further the research, Adrian S. Ray and Richard L. Mackman from Gilead Sciences Inc. entrusted United States Army Medical Research Institute of Infectious Diseases, CDC, University of North Carolina to do researches in different fields respectively, which are the places those papers online came from. The leaders of those projects were Sina Bavari (Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys) (Warren, et al., 2016), Christina F. Spiropoulou (GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses) (Lo, et al., 2017), Ralph S. Baric (Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses) (Sheahan, et al., 2017). All the samples of SARS used in our experiments so far have come from the team led by Professor Baric since he is an expert of making SARS, publishing the paper Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus (Yount, et al., 2003), which means that he could have SARS virus duplicated without limits since then in 2003. He also offered fundings for Chinese Academy of Sciences for researches and made Zhengli-Li Shi the naive Snow White who helped him locate gene variation fragments for transforming SARS in Southern China.
In fact, Zhengli-Li Shi has completed the task Professor Baric gave her since the gene fragment SHC014 she discovered in China was adopted by Professor Baric to synthesize into a new type of virus in the Fort Detrick Laboratory in 2015 which is the COVI D-19 today.
That is a great experiment, and a huge progress we made in virusology and biology considering that the synthesis of RNA is unprecedent. Professor Plummer had been against this experiment, believing that it went against scientific ethics. However, Professor Baric and Gilead Sciences Inc. insisted that the synthesized virus could be taken as the reference for the original SARS in contrast experiment, and the essential subject for experiments on GS-5734.
As far as I recall, artificially breeding new type of SARS should be a research and development project for developing biological weapons entrusted by Department of National Defense (DOD). However, Gilead Sciences Inc. also had their own secret plan that they would sell GS-5734 to all over the world at a very lucrative price once the virus is leaked and spreads.
To clarify, the global widespread of COVI D-19 was not an intentional action done by Gilead Sciences Inc. or DOD but the consequence of an experimental leakage. In May, 2019, there was a leak in our experiment but we were not aware of it until villagers near labs in Maryland was infected, which was monitored by CDC in July 2019. It was too late when we found out that there were serious problems with the waste water treatment system in our lab.
Those speculative facts circulating on the Internet are not totally accurate since the rampant influenza then in South America was not totally SARSII (COVI D-19) but two kinds of viruses spreading at the same time. The outpost labs located in various states did not run tests on the coronavirus due to the Interference of CDC.
Based on the advice from Professor Baric, neither our lab nor the military and Gilead Sciences Inc. would admit the source of virus but we all tacitly referred to bats in Yunnan province in China as the source of the virus. This is possible based on the experiments and papers with Chinese scientists' involvement having proved the gene variation in nature, and the stereo type that SARS-I originated from China.
There were some controversial issues during the spread of COVID-19. In order to ensure the virus would not make irreversible damages, CDC initiated the EVENT201 drill with the assistance of CIA. Despite the
unsatisfying performance, Professor Baric believed that SARS-II would not do huge damages to Caucasians in America due to the different distribution of ACE2 in different races. This is the reason why CIA finally decided to withhold the pre-warning of the spread of the virus.
Professor Baric, Gilead Sciences Inc., BlackRock (a subcompany of Gilead Sciences for investment) and CDC are all the decision makers of the whole thing. All the members of the meeting were republicans and report to Office of American Innovation and Jared Kushner.
Then, December in 2019 was the turning point when a sailor who continued to work after being infected by SARS-II, and happened to seal the virus into the package of seafood which was transported into seafood market in Wuhan, China through the illicit market. Unexpectedly, Chinese epidemic prevention departments found out the virus, which, could probably be thanks to their prevention experience of SARS. Otherwise, the viral pneumonia could have been treated as bacterial pneumonia and named as a new type influenza without triggering enough attention.
After Chinese government found about SARS-II, my supervisor Professor Plummer was planning to share with Chinese scientific research institutions how GS-5734 could be adopted to fight against SARS-II, but he was assassinated when he was flying from Kenya to China. And I had to come back to India and hide since I got the news.
As far as I know, some colleagues knowing the truth have been killed during the last few months and some others just disappeared. All the other practitioners bowing to Professor Baric do not dare to express their doubts without the permission of him. Once their doubts was proposed, their career will be over since no publications will accept their paper any longer.
I have no idea how long I will live in this world and I feel so guilty deep down in my heart. I could not let so many lives gone even without being aware of the truth, so I make it known to the public and may Lord Shiva bless all of you. They would of course deny all of it, and even deny my identity or the existence of me. They will do whatever within their power to get me killed. So I would say goodbye right here. Farewell to all of you! I am so sorry!
19 日晚，热搜第一的关注度“爆”了！
据外交部官网消息，1 月 18 日，外交部发言人华春莹主持例行记者会。有记者提问，日前，美国国务卿蓬佩奥在国务院网站发表声明和事实清单，称其掌握中国政府实验室活动新信息，攻击中国阻碍病毒溯源和进行“虚假宣传”，指责武汉病毒研究所人为制造及泄露病毒，武汉病毒研究所同军方秘密合作等，强调必须对新冠病毒起源进行全面且不受限制的调查。请问中方有何评论？
对此，华春莹回应称（滑动查看）：
美国彭博社也给我们发来了这个问题单。你提到的这个声明和清单充斥着阴谋论与谎言，这与美国个别政客对内消极抗疫、对外竭力“甩锅”的作风一脉相承。所谓事实清单不过是美方炮制的又一篇谎言清单，充分反映了美方有关政客为一己私利而置公众安全于不顾，漠视生命、违背科学，沉迷宣扬阴谋论、热衷散播“政治病毒”的态度。这是蓬佩奥这位“谎言先生”的“最后疯狂”。
上述文件中提到的所谓中国政府阻止溯源调查和进行“虚假宣传”与事实完全不符。面对未知的新冠病毒，中方第一时间为全球抗疫拉响了警报，第一时间公布了病毒基因序列等关键信息，第一时间采取了最全面、最彻底、最严格的防控举措，取得重大阶段性成效，为国际抗疫争取了宝贵时间。世卫组织和多国科学家认为，中国采取了历史上最勇敢、最灵活、最积极的防控措施，改变了疫情快速扩散流行的危险进程，减少了数十万病例的发生。疫情发生以来，中方本着开放、透明、负责任态度，率先同世卫组织开展溯源合作，一直同世卫方面保持着密切沟通。去年 2 月和 7 月，中方在国内抗疫任务十分繁重的情况下，两次邀请世卫组织专家来华开展溯源国际合作。上周，世卫国际专家组已抵达武汉，同中方专家开展新一轮溯源科研合作和交流。反观美方，个别政客将是否佩戴口罩这种基本的防疫措施都政治化，在媒体等公开场合散布关于新冠肺炎疫情的不实信息，长时间蓄意淡化疫情，扰乱视听，违背科学，误导民众。
所谓新冠病毒来自实验室以及武汉病毒研究所秘密军方背景的论调都毫无科学和事实依据。这份所谓清单中的观点和信息自相矛盾、错漏百出，根本站不住脚。世界上几乎所有顶级科学家和疾控专家，包括美国顶级疾控专家都已经公开予以否定。同武汉病毒研究所合作长达 15 年之久的美国病毒专家达萨克早在去年 4 月接受美国有线电视新闻网采访时就表示，“武汉病毒实验室尚未拥有引发新冠肺炎疫情的病毒，所以病毒源于武汉实验室是不可能的”。中方相关科学家们也多次接受媒体采访，美国媒体也去过武汉病毒研究所进行实地参观采访，从专业角度介绍有关管理和研究等情况。中方媒体已就疫情发布了谎言与真相系列，援引大量具体、详实数字和事实进行了深入批驳。美国政府对这些真正的事实视而不见、充耳不闻，恰恰说明在美方个别政客眼中，只要能够攻击抹黑中国，谎言也可以变成“事实”。
华春莹还强调，如果美方真的尊重事实，就请开放德特里克堡基地，并就美海外 200 多个生物实验室等问题公开更多事实，请世卫组织专家去美国开展溯源调查，回应国际社会关切，用实际行动给国际社会一个交代。希望美国个别政客，尊重科学，拿出起码的良知，停止搞“甩锅”和政治博弈把戏，为国际溯源合作和国际抗疫合作提供一个良好的环境。这才是现在应该做的事情。
关于德特里克堡生物实验室
你不知道的秘密
来源：央视新闻
一时间，德特里克堡基地引发关注。据 @CGTN 消息，位于马里兰州德特里克堡的美国陆军传染病医学研究所（USAMRIID）是美军最重要的生物防御技术研究机构，储存有埃博拉病毒、炭疽杆菌、布鲁氏菌等致命“特定生物制剂与毒素”。
关于德特里克堡生物实验室你不知道的秘密 视频来源：@CGTN
2019 年 7 月，美国疾控中心要求该研究所暂停对高致病性病原体的研究工作，疾控中心在该机构发现 6 处违反联邦安全规范，包括废水净化系统故障造成泄露等，但美国疾控中心以“国家安全”为由拒绝公布更多细节。而该所曾多次出现安全事故，包括生炭疽等致命菌株、毒株丢失事件。
图为位于美国马里兰州德特里克堡的美国陆军传染病医学研究所 ( USAMRIID ) 的技术人员，在一个遏制埃博拉病毒的实验室里进行化验。
据中国新闻网消息，当时，美国民众提出疑问：其“闭关”时间，与新冠疫情大流行存在时间上的部分重叠；且这座专攻生物化学研究的基地，会不会与新冠病毒存在关联？美国政府的解释，却显得牵强。